Amitrip is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Amitrip does not affect mood or arousal, but may cause sedation. In depressed individuals, Amitrip exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Amitrip, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e. g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitrip may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).
Other names for this medication:
Amitriptyline,
Elavil,
Amineurin,
Amitril,
Amitrip,
Amitriptilina,
Anapsique,
Deprelio,
Eliwel,
Laroxyl,
Lentizol,
Levate,
Mutabase,
Mutabon,
Redomex,
Saroten,
Sarotena,
Sarotex,
Tryptanol,
Tryptizol,
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Prolok,
Clofen,
Clomipramina,
Hycid,
Lokit,
Zolt,
Pantocid,
Amoxistad,
Trant,
Cosudex,
Medazol,
Taclar,
Trichodazol,
Ketovid,
Ilsatec,
Drusa,
Olexin,
Trizolin,
Pantac,
Symoxyl,
Fexidine,
Topraz,
Azitrocin,
Prostol,
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Clavoxine,
Klabax,
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A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied by multiple endocrine neoplasia type-1 infection urinaire traitement sans antibiotique monozeclar (MEN-1) is reported. Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia.
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