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Looking back whilst moving forward: observations on the science and application of integrated care over the past 10 years and predictions for what the next 10 years may hold. The first full genome sequences were established in the mid-1990s. Stroke prognosis in diabetes mellitus: new insights but questions remain. Membranes were generated by randomly distributed pores with a given pore size distribution on a two-dimensional plane.

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The Spielberger Inventory Trait and the Center for Epidemiologic Study-Depression (CES-D) scales were used to evaluate anxious and depressive symptomatology respectively. Effects of receptor-selective neurokinin agonists and a neurokinin antagonist on the electrical activity of spinal cord neurones in culture. The UDP-glucuronosyltransferases (UGTs) are integrally involved in the clearance of a wide range of drugs used to combat human diseases. These results add to the growing evidence supporting the clinical and research value of measuring pulmonary dead space in patients with acute respiratory distress syndrome and using this pulmonary physiologic end-point as one indicator of a favorable response to therapy.

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Correction of the secondary nasal deformity in bilateral cleft lip with a new technique All patients were symptomatic of choroidal metastases at presentation. Prospective Swiss cohort study of living-kidney donors: study protocol. Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis. Subsequently, the biochemical and morphologic criteria of MMS-treated cells were examined.

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A methodology for the adaptive control and correction of phase aberrations in the illumination arm of a light-sheet fluorescence microscope has been developed. Integrated notification and laboratory-based surveillance of meningococcal disease provides relatively complete surveillance of this disease in New Zealand and has supported the development of public health interventions.

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Polyamidoamine dendrimers (PAMAM) were modified with angiopep through bifunctional PEG, then complexed with DNA, yielding PAMAM-PEG-Angiopep/DNA nanoparticles (NPs). A new SEIR epidemic model with applications to the theory of eradication and control of diseases, and to the calculation of R0. Reactivation of varicella zoster virus (VZV) from latently infected human ganglia usually produces herpes zoster (shingles), characterized by dermatomal distribution pain and rash. An unusual case of this complication is reported and the possible etiology and pathogenesis are discussed. Bronchogenic squamous carcinoma in nonirradiated juvenile laryngotracheal papillomatosis.

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The findings from this study suggest that victims of child maltreatment are at increased risk for financial and employment-related difficulties in adulthood. 5-azacytidine-induced alterations in the GH12C1 cells: effects on cellular morphology, chromosome structure, DNA and protein synthesis.

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Randomized controlled trial to evaluate synergy between taxane plus platinum chemotherapy and CADI-05, a Toll like receptor-2 agonist targeting desmocollin-3 as a first-line therapy in advanced non-small-cell lung cancer (NSCLC). Adverse gastrointestinal events are commonly observed in dogs receiving vincristine.

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Type II endometrial cancers are not associated with a history of unopposed estrogens and develop from the atrophic endometrium of elderly women. The T790M mutation is common in patients with acquired resistance. Cell survival and proliferation after encapsulation in a chemically modified Pluronic(R) F127 hydrogel. We recently experienced a case of transoral endoscopic thyroidectomy via the trivestibular approach. Although similar suppressor patterns are observed, percent Black is generally unrelated to outlet density.

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Counter-regulation of basal insulin secretion during alcohol hypoglycemia in diabetic and normal subjects. A 57-year-old woman ingested red-dyed pellets of anticoagulant rodenticide containing difethialone and warfarin as well as tablets of nitrazepam.

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To provide a basic anatomical study of clinical endoscopic surgical approach, we investigated the pterygopalatine fossa anatomy through lateral wall of the nasal cavity approach under endoscopy. We present our CP modeling approach that features the integration of multiple localized CP to realize a unified disease-specific CP. Coexistence of hyperthyroidism and diabetes in a 12-year-old girl Atherosclerosis is caused by a series of pathologic changes at the cellular level, with formation of macrophage-derived foam cells occurring at an early stage. Yaws was detected in a six-member family in the southern Malaysia state of Johor.

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In other instances, the therapy for certain diseases is responsible for the reduction in NO activity and contributes to the acceleration of vascular disease. Although peginterferon alfa-2b was safe, because of the lack of HCV transmission in either the treated or untreated groups there is little evidence to support routine postexposure prophylaxis against HCV in HCWs. Here, we describe the current methods that enable researchers and/or clinical microbiologists to accurately detect echinocandin-resistant isolates of C. Constitutive biosynthesis of bone Gla protein in a human osteosarcoma cell line.

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This indicates that developmental modifications of mechanical transmission in the external and middle ear or cytodifferentiation of the sensory hair cells of the basillar papilla and the neurons of the acoustic nerve continue postnatally. The need to develop a multidisciplinary expertise for the microbiological safety of operating theatres.

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Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15. The aim of the present study was to provide data on localization, intensity and frequency of adolescent spinal pain and to investigate which physical and psycho-social parameters predict these pain characteristics. This outbreak has been characterised by extensive geographic spread across the affected countries Guinea, Liberia and Sierra Leone, and by localized hotspots within these countries. Use of video capsule endoscopy in a patient with an implantable cardiac defibrillator. The effect of asparagine deprivation on the translation of messenger RNA in reticulocyte lysates.

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Development of a novel polystyrene/metal-organic framework-199 electrospun nanofiber adsorbent for thin film microextraction of aldehydes in human urine. To retrospectively review outcomes following angioplasty of nonmaturing autogenous hemodialysis fistulas. The program targets multimorbid patients at high or moderate risk of cardiovascular disease with uncontrolled hypertension, dyslipidemia or diabetes. It is possible that the prolonged life span of adult podocytes is associated with a slow turnover of CR1 and low or intermittent accumulation of CR1 mRNA transcripts. The relationship between metastatic lesions and the degree of appearance of plasma cells in regional lymph nodes affected by carcinoma of the stomach was observed in this study.

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High resolution with access to the fetal head makes this modality ideal for studying the intracranial anatomy. The absence of a European Medical Language System project is observed, as is the need for combinatorial as opposed to enumerative systems. The identification of a molecular signature specific for ALCL suggests that these T-NHLs may represent a unique entity discernible from other PTCLs, and that a restricted number of genes can be instrumental for clinical stratification and, possibly, therapy of T-NHL.

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T11TS induces downregulation of the cyclin-D (1 and 3) expression with the concurrent upregulation of p21 and p27 and their concomitant association with cyclin-dependent kinase 4, proliferating cell nuclear antigen and cyclin E respectively leading to a decrease in cyclin-dependent kinase 4 kinase activity. Synthesis and reactivity of enantiomerically enriched thiiranium ions. Elimination of the hypophysis for treatment of diabetic retinopathy: selection of patients for hypophysectomy Compare survival in patients with multiple sclerosis (MS) from a U.S.

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