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This tolerance develops with both long- and short-acting beta-agonists and is not affected by treatment with inhaled steroids. We also investigated the impact of lncRNAs on its target genes in cis and trans, indicating that these lncRNAs have a strict tissue specificity and functional conservation during skin development and pigmentation. Prognostic evaluation of immunohistochemical profiles in diffuse large B-cell lymphoma: a Chinese study. Lipoprotein secretion in lean and obese Zucker female rats in vivo and in a single-pass-perfused liver preparation.

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IL-8 and TNF-alpha from peripheral neutrophils and acute-phase proteins in periodontitis. Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus. Conversely a relative response can be measured against stored target cells. It has long been recognized that birds and bats are characterized by lower rates of extrinsic mortality and greater longevities than nonvolant endotherms, presumably because flight reduces exposure to terrestrial predators, disease, and environmental hazards.

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Lovastatin reduced the cholesterolemia in the dislipidemic patients. The disposition of antiarrhythmics is dependent on many factors, such as administration route, stereoselectivity in the first-pass effect, inhibition of enzymes, polymorphisms, etc. Amphibian metamorphosis serves as an excellent model to study T3 function during postembryonic development in vertebrate due to its total dependence on T3.

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The type of fortificant and the leaf matrix both influence iron and zinc bioaccessibility in iron-fortified green leafy vegetable sauces from Burkina Faso. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes.

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Asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles and 3-nitroindoles with amino-thiocarbamate catalysts: enantioselective synthesis of polycyclic spirooxindoles. We show here that the other lateral neurons also arborize in the accessory medulla, predominantly forming postsynaptic sites. Risk factors for placenta accreta include placenta previa, abnormally elevated second-trimester AFP and free beta-hCG levels, and advanced maternal age. The depletion depended on the concentrations of styrene and on the degradation temperature.

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Like any other scientific field, pharmaceutical granulation technology also continues to change, and arrival of novel and innovative technologies are inevitable. A recombinant 50-kDa species (Tyr112-Val524) expressed in cells exhibited enzymatic activity against pro-MMP-2 and galectin-3, and thus this species is a competent protease. Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus. Iontophoresis of a 13 kDa protein monitored by subcutaneous microdialysis in vivo.

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The MLC of RKM (0.3 micrograms/ml) was the same as that of OFLX and was significantly lower than that of other drugs tested. The frequency of many major pathologic placental features, especially ischemic changes and meconium, in the absence of immediately detectable abnormality is relatively high. An observational and cross-sectional study of a consecutive sample of children between 6 and 14 years old who were seen at the Childhood Pneumology clinics from 15th January to 15th February 2009. Brains obtained at autopsy from l-deprenyl-treated Parkinsonian patients showed that, whereas MAO-B was fully inhibited by the therapeutic doses of l-deprenyl, substantial MAO-A activity was still evident. Augmentation of clozapine with a second antipsychotic - a meta-analysis.

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An evaluation of the relative importance of host and pathogen factors on the survival rate of patients with invasive Streptococcus pyogenes infection found a number of clinical and demographic factors to be associated with risk for death. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. This is suggested by the fact that patients with meningiomas or gliomas of the chiasmal-cellar site without anaplastic signs exhibit much higher blood levels of lipid-conjugated acids than those with the similar tumors of the hemispheric site. In developing muscle, both in vivo and in vitro, there is a development-related progression from synthesis of primarily large proteoglycans at earlier stages to mainly small proteoglycans at later stages.

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These 2 phosphopeptide preparations were shown by carbohydrate analysis to be free of keratan sulfate-containing peptides or peptides from the hyaluronic acid binding region of the core protein. Binding of anti-EMA, AGF 4:48 and the lectin UEA-1 to human ovarian carcinomas: histological and clinical correlations. AM resistance to LT may enhance clearance of the pathogen from the alveolar surface and explain why this surface is relatively free of B.

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The incidence of prostate cancer varies enormously throughout the world. These capabilities are illustrated by simple example grammars expressing how gene expression rates are dependent upon single or multiple parts. The degree of preference is, however, small in relation to the total amount of immunoglobulin transported.5. Transforming growth factor-beta is important for the stimulation of the fibrotic response by promoting the production of extracellular matrix proteins, by promoting the differentiation of the myofibroblast cell morphology, and by protecting these cells against apoptotic stimuli.

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CHCs remained qualitatively stable within each species, right down to the isomer level. Mini-incision donor nephrectomy (MDN) has proven to be an effective and less invasive modification of classic ODN. Staining in high grade prostatic intraepithelial neoplasia was moderately up-regulated vs that in normal prostate tissue adjacent to tumor but generally less intense than in carcinoma tissue. The study population consisted of 1603 consecutive patients with acute MI who were recruited from nine clinics, located in three cities, and 699 unrelated adults who were randomly selected from the city catalogues. Two polypeptide chains are present in murine beta-glucuronidase precipitated with a specific anti-beta-glucuronidase antibody F(ab)2 fragment.

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Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease. We used the Constant score and the disabilities of the arm, shoulder and hand (DASH) scale to determine the outcomes. Implications of environmental pharmacology and toxicology: food sources of incidental drug exposure. We performed observational study on 1622 patients with mCRC treated with bev plus oxaliplatin- or irinotecan-based chemotherapy, and correlated treatment outcomes with KRAS mutation status.

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Persistence length and scaling properties of single-stranded DNA adsorbed on modified graphite. This method yielded sperm suspensions free of seminal plasma and populations of spermatozoa that had increased motility ratings compared with the original semen. Altered mechanotransduction, poorer activation of satellite cells, poorer chemotactic and delayed inflammatory responses, and a change in modulators of the ECM are important cellular changes. In this Article, we report the application of the quartz crystal microbalance (QCM) to study the evaporation of colloidal suspension droplets.

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Helicases appear to be important for genome stability of dormant Mycobacterium tuberculosis responsible for latent tuberculosis infection and big proportion of active disease cases caused by reactivation. The MaxEnt Jackknife procedure was used to minimize the number of environmental variables that showed an influence on final models.

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CT seems to be sufficient in T1a GBC patients but inadequate in T1b (stage IA), which requires a more aggressive approach. Symptoms included nausea (37 of 37), vomiting (31 of 37), weakness (29 of 37), headache (22 of 37), and palpitation (two of 37). The oviposition choice of an insect herbivore is based on a complex set of stimuli and responses. Of these, 167 lived in nursing homes and 975 lived in the community.

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People undergoing endoscopic surgery were more likely to have a haematoma. Since 5-HT is known to act as a trophic factor for its own development and its target areas, exposure to 5-HT antibodies during birth might have adversely affected the development of the serotoninergic system and resulted in long-lasting changes in behavior and 5-HT levels in the brain. Timing and frequency of artificial insemination in women under menotropin therapy. Serologic evidence of frequent human infection with WU and KI polyomaviruses.

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The effects of Ro 5-4864 (chlordiazepam) were examined on responding for self-stimulation of the mid-lateral hypothalamus. It is postulated that the interactions of these cytokines with their receptor complexes evolved independently of GAG binding, with GAG binding being an additional feature for a subset of this cytokine family. Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Together, our results suggest that tnnc1a is required both for the function and structural integrity of the contractile machinery in cardiomyocytes, helping to clarify potential mechanisms of troponin C-mediated cardiomyopathy.

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Auxiliary beta subunits are critical determinants of membrane expression and gating properties of voltage-gated calcium channels. Focus groups among health care workers were conducted at one of the largest Veterans Administration hospitals to determine reasons for under-reporting. CEA, a well established marker for benign and malignant colonic tumors is widely used for tissue staining and body fluid measurement. T cells function via restricted recognition of antigen, not antigen-restricted recognition.

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Structural and functional identification of complement components of the bony fish, carp (Cyprinus carpio). To determine the relative contribution of each of these factors to overall dyspeptic symptom severity and weight loss in FD. Data from 51 patients (2008 to 2013) were analyzed in this retrospective single-center study. The diagnosis and management of thrombocytopenia is a growing component in the practice of hematology. Although commercialized transcatheter stent-mounted pulmonary valves are effective treatment options for improving functional class and for normalizing right ventricular volumes in such patients, they are not available in Taiwan.

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Intensity of stimulus and effects of oliguric-hypertensive reflex from urinary bladder Anatomy of the normal knee as seen by magnetic resonance imaging. Treatment with exogenous estrogen in combination with HCG enhances both the magnitude and duration of this constricture.

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The Kyoto Prognostic Index for patients with diffuse large B-cell lymphoma in the rituximab era. Plasma LH, progestins and corticoids in heifers injected with estradiol valerate and FSH during estrous synchronization with MGA.

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The objectives of the study were to explore mechanisms underpinning IR by assessing the effect of exercise training on IR and body composition in overweight PCOS and non-PCOS women. Besides the improvement of diagnostic tests for acute appendicitis, we could not sufficiently reduce the negative appendectomy rate. For T1a prostate cancer incidentally detected on transurethral prostate resection p53 and bcl-2 immuno-expression, and DNA ploidy do not predict survival or disease progression. Nurses were recruited using a striated cluster sampling approach.

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Detailed simulations are done to evaluate the performance of the system, and the sensitivity of the system to estimation error is presented. Many patients who did not receive nalbuphine were able to breathe adequately at an earlier stage than was previously suspected.

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This study suggests that total and phosphorylated MET expression in tumor tissue is potentially useful for the selection of NSCLC patients who are likely to benefit from EGFR-TKIs, irrespective of their EGFR status. Congenital spirochetosis in calves: association with epizootic bovine abortion.

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Evaluation of the non-surgical approach in apical endodontic lesions. Providers may be deferring immunizations until infants are clinically stable, or may have a higher threshold for initiating sepsis evaluations after immunization than at other times. Oral history has a unique role to play in recording the detailed aspects of nursing practice which are often difficult to reconstruct from documentary sources alone. Some typical effects of therapeutic intervention in time series designs are considered and suggested for heuristic evaluation by Kendall-tests.

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We describe a case of polymicrobial bloodstream infection with six organisms identified by multiplex PCR that was initially thought to be a monomicrobial infection. Gene expression was assessed in three genetically and phenotypically divergent commercial wine strains (CEG, VL1 and QA23), under low (67 mg/L) and high nitrogen (670 mg/L) regimes, at three time points during fermentation (12 h, 24 h and 96 h). Given the rarity of brain death in clinical practice, trainees may complete their training without ever performing a brain death exam.

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However, detailed mechanisms of this process and interactions between inflammatory agonists and angiotensin II in promoting retinopathy are poorly understood. Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells. Testicular androgen production by the Leydig cells is almost entirely dependent on LH/hCG action, while in the ovary LH triggers both oestrogen and progestin secretion and ovulation of the Graaffian follicles.

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DNA polymerase makes errors by misincorporating natural DNA bases and base analogs. Moreover, the results of statistical analysis suggest that August rats are less resistant to stress than Wistar.

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At 120 days, ADR-induced RI was observed to be dose dependent in both femoral marrow and spleen. Cognitive Abilities, Social Adaptation, and Externalizing Behavior Problems in Childhood and Adolescence: Specific Cascade Effects Across Development. Open versus robot-assisted surgery was investigated in 3 studies. Here, we used an in vitro co-culture approach comprising interaction between immune (bone marrow-derived mast cell, BMMC) and nerve cells (superior cervical ganglia, SCG). A 77-year-old man presented with a 4-year history of progressive dysphagia to the point that he could no longer swallow solid foods.

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Double-flash discrimination was consistently more sensitive than any of the clinical variables measured and in some cases complementary to them. Quantitative changes of zinc content in the hippocampal region after dithizone administration

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The methods were evaluated with respect to scan-rescan reliability and an application to normal aging. Molecular characterization of the myxosporean associated with parasitic encephalitis of farmed Atlantic salmon Salmo salar in Ireland. Intramuscular (i.m.) injection of mice with 2000 IU/g of essentially pure murine interferon-alpha/beta (MuIFN-alpha/beta) 3 h before the induction of IFN by an intraperitoneal (i.p.) inoculation of 10 haemagglutinating units (HAU) per g Sendai virus or 3 micrograms/g polyriboinosinic and polyribocytidylic acid complex (poly rI:rC) elicited a primed IFN response in both cases. Eicosanoids are oxygenated, endogenous, unsaturated fatty acids derived from arachidonic acid. Piezoelectric constants for ZnO calculated using classical polarizable core-shell potentials.

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FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia. A case study of a woman who sustained a self-inflicted transoral gunshot injury that resulted in focal pathology to the frontal lobes. To confirm that demyelinating diseases (DD) cause increased urinary FLCs.

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The C3H female mice were implanted with 2 x 10(5) cells of KHT, a murine sarcoma. The metabolic profile of the February and July communities, determined using Biolog EcoPlates, also suggested that temporal variation occurred within the bacterial populations that colonized the headbox of the paper machine. Isolated uterine nucleoli contain a large number of lower-affinity binding sites (Type II) but are devoid of a significant number of high-affinity binding protein(s) (Type I). The effect of vitamin D deficiency in pregnancy is unknown, but has been associated with adverse pregnancy outcomes.

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Outstanding symptoms of this anomaly were bouts of respiratory difficulty with espiratory wheezing. Previous studies have shown that the chemiphosphorescent emission observed in the enzyme-catalyzed reaction is due to the production of acetone in its triplet state. We aimed to determine the effect of a PDE4 inhibitor, rolipram, on human detrusor contractions. Creating a culture of safety: why CEOs hold the key to improved outcomes.

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The supernatants of C6 glioma cells and T9 gliosarcoma cells suppressed the proliferation of the endothelial cells. This report describes two probable cases of fatal laboratory-acquired meningococcal disease and the results of an inquiry to identify previously unreported cases. In surveillance programs, endoscopy is important in detecting secondary gastric carcinomas, whereas ultrasonographic examination has no clinical value.

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DNA fingerprinting data and the problem of non-independence among pairwise comparisons. The present study adds experimental evidence and provides a unified macroscopic explanation to this anomalous behavior from differences in average adsorption capacities, and not in average adsorption affinities. Further research is required in order to estimate precisely the cost-effectiveness of this compound, particularly including indirect costs and in other countries.

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The aim of this study was to evaluate the impact of diabetes duration on long-term clinical outcomes after drug-eluting stent (DES) implantation or coronary artery bypass grafting (CABG). The latter finding suggests that this type of genomic organization was already present in the common ancestor of these bird species and remained unchanged over a long evolutionary time. Equivalent doses of CdMT induced MT mRNA accumulation to an equal degree in kidney and liver.