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Piramax (Topiramate)
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Topiramate

Piramax is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Piramax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Piramax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Piramax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Piramax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Piramax as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Highly c-oriented aluminum nitride (AlN) thin piezoelectric films have been grown by pulsed direct-current (DC) magnetron reactive sputter deposition. A 22-year-old patient with a 16-year history of ulcerative colitis who developed multifocal anaplastic colon cancer is presented.

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PTSD can damage functional capacity and interfere with social functioning. This compound is a precursor of the phospholipid, phosphatidylethanolamine. These data indicate that loss of p57(KIP2) is a frequent event in HCC, especially in poorly differentiated HCC, suggesting that p57(KIP2) might play a role in the differentiation of HCC. The data are consistent with the hypothesis that this may be due to genetic factors.

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Patient-level data were available to external researchers either directly or through application and review (which may include usage fees) for 13 of the 48 registries, and were inaccessible or accessibility was unknown for 25. Different functional observations in the use of siRNA versus asONs indicate the relevance of this assumption.

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Low Dose BCG Infection as a Model for Macrophage Activation Maintaining Cell Viability. Daily carbon gain by mother cladodes was reduced as the number of daughter cladodes increased to eight, especially during drought. Despite the recent progress in the identification of genes involved in PA biosynthesis, the mechanisms involved in subunit condensation, galloylation, or fine regulation of the spatio-temporal composition of grape berries in PAs are still not elucidated.

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Acetaminophen elimination kinetics in neonates, children, and adults. We investigated the kinetics of this process in vitro by using full-length ICAM-1 target RNA and biologically active and inactive ICAM-1-directed siRNA, respectively.

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The effect of warfarin on plasma clotting time in wild house mice (Mus musculus L.). In this work, a young female subject with major neuromuscular dysfunction of the left lower limb, which resulted in an asymmetric hemiplegic gait, participated in a series of FES-assisted walking experiments. A dose of 400 R limited but did not prevent an increase alpha- and beta-globulins upon subsequent infection. Cultural transmission theory leads to a prediction of a strong African versus non-African phylogeographic pattern in handaxe datasets, if the African Acheulean hypothesis is to be supported.

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The reduction by atropine of the acid and serum gastrin responses varied among the cats but were correlated significantly. Population and mutation analysis of 17 Y-STR loci from Rio de Janeiro (Brazil). Panic disorder patients had a deficient GABA neuronal response (blunted reduction of occipital cortex GABA level) to acute benzodiazepine administration, compared to the healthy subjects, who exhibited a significant decrease in occipital cortex GABA levels after this intervention.

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One aspect of this project was the logging method used by students. Furthermore, the computational model itself can provide biological information as to which are the dominant features that characterize these regulatory units. We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. An evolutionary ecological perspective on demographic transitions: modeling multiple currencies. This review addresses the current mechanisms of immune dysregulation in the development of multiple sclerosis, including the impact of environmental risk factors on immunity in both multiple sclerosis and its animal models.

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Preincubation of W256 and B16a cells with doses of alpha-thrombin from 0.01 to 10.0 U/ml produced a bell shape dose-response curve with the maximal effect (a 2-5-fold increase in adhesion) observed at 0.1 U/ml (corresponding to 0.8 nM). The patient underwent wide resection and biopsy of the tumor site. His hearing loss was very severe and showed no improvement despite adequate antibiotic treatment. Radiographic visibility of periodontal ligament spaces of related teeth was assessed.

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Seven TAA systems were removed due to loosening or subsidence, suggesting component damage/wear may lead to clinically observed component loosening. Mothers bottle feeding their babies feel negative emotions such as guilt and worry, and receive little information about bottle feeding.

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Liver stiffness measurement, 13C-aminopyrine breath test, indocyanine green plasma clearance, and APRI score are reliable noninvasive methods for the diagnosis of cirrhosis in patients with chronic liver diseases of various causes, and are also prognostic indicators for the occurrence of severe complications in cirrhotic patients. Incidental identification of Brucellosis in a patient with a gun-shot injury. Cell cycle arrest at the G1 phase was induced only in the SiHa and HeLa cells, suggesting that exogenous infection of Adp53 in cancer cells was significantly different from the other HPV-associated cervical cancer cells.

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In addition, oxide ion conductivity at a low temperature range (100-200 degrees C) was obtained, and the activation energy for diffusion in gadolinia-doped ceria (GDC) was calculated as approximately 0.56 eV, implying that the majority of oxide ion vacancies diffuse on the surface rather than inside the bulk of the electrolyte. Self-care agency and adherence to treatment in people having cardiovascular risk The effect of aging on thyroid hormone metabolism and its clinical implications Although it is accepted that furrows and exudates appear to represent areas of inflammation, no research to date has looked specifically at EoE endoscopic findings to see if eosinophilic infiltrate correlates with specific endoscopic findings.

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Serum PCR was accurate in detecting the infection in the early stages in this asymptomatic neonate. The first report regarding SOD activity of metallocorroles, investigated via the combination of the cytochrome C assay, pulse radiolysis, and electrochemistry, is used for identifying the main criteria needed for achieving good performance, as well as for elucidating mechanistic aspects of their action. Hypocretin-1 levels were consistent with this pattern, although the differences were not as marked. Proanthocyanidin administration significantly suppressed gastric mucosal injury, induced by water-immersion restraint stress, in a dose-dependent manner.

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Attention deficits are not characteristic of schoolchildren with newly diagnosed idiopathic or cryptogenic epilepsy. These data altogether have shed a new light on the pathophysiology of the first molecular disease i.e. In addition, during the attenuation process, sequence analyses showed changes in the pattern of the parasite subpopulations. In group 3b basal and peak LH levels were lower on day 7 compared to group 3a, whereas FSH levels did not differ.

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More importantly, patient J.Y., who had anti-platelet antibodies, responded dramatically to high doses of prednisolone. Neither ATP nor a deaminase inhibitor blocked the effect of microglial CM. The absence of muscle contractions seems to be deleterious to normal human knee cartilage even in the presence of a normal range of motion.

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This study argues in favor of further dissemination of DANCIN in care homes. Across all analyses, we found highly congruent patterns of differentiation suggesting species level divergences between morphotypes. Temporal and spatial response asymmetries surface as critical factors underlying disequilibrium associated with localized cerebrovascular lesion. Such foraging tasks raise questions about how observers maximize target collection - e.g., how long should one spend at one berry patch before moving to the next patch.

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To determine whether the angiogenic peptide vascular endothelial growth factor (VEGF) is sufficient to produce iris neovascularization in a nonhuman primate (Macaca fascicularis). We propose that each retinotopic motion vector creates a reference-frame field in the retinotopic space, and that the fields created by different motion vectors interact in order to determine a motion vector that will serve as the reference frame at a given point and time in space. Establishment of a human B cell line that proliferates in response to B cell growth factor. In uncommon and rare diseases, the AUPRC should be preferred to the AUC because it summarizes better the performance of a biomarker.

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A new ferredoxin-dependent carbon reduction cycle in a photosynthetic bacterium. In a study group of 2,457 consecutive patients undergoing cardiac catheterization, 30 patients had coronary arterial ectasia, an irregular dilatation of major vessels up to seven times the diameter of branch vessels. Myocardial infarction and stroke are both predominantly manifestations of atherosclerosis, yet stroke is commonly ignored in prognostic studies and therapeutic trials of ischemic heart disease. Marginal Structural Models: unbiased estimation for longitudinal studies. Although several cytokines, including IL-1 and TNF, are implicated in the acute-phase response, recent evidence is that the synthesis of the major acute-phase proteins (e.g.

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Overwhelming maternal cell contamination in amniotic fluid samples from patients with oligohydramnios can lead to false prenatal interphase FISH results. Subjective cognitive complaints included in diagnostic evaluation of dementia helps accurate diagnosis in a mixed memory clinic cohort. Maximum adhesion was observed in the duodenum, followed by the jejunum and ileum. The competition between simple and complex evolutionary trajectories in asexual populations. Activation of NF-kappaB is thought to involve recruitment of IKK signalosomes at the surface of the macroschizont stage of the parasite, and it has been postulated that additional host proteins with adaptor or scaffolding function may be involved in signalosome formation.

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paracasei CNCM I-4034 significantly increases the release of pro-inflammatory cytokines, enhances TLR signaling pathway activation and stimulates rather than suppresses the innate immune system. The mechanical treatment of molars under adverse anatomical conditions The clinical profile of patients with Clostridium difficile diarrhoea varies by place of acquisition of infection.

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Intermittent preventive treatment with SP has shown clear superiority in reducing adverse outcomes at delivery, as compared with intermittent preventive treatment with CQ and classical chemoprophylaxis with CQ. Contribution of heteromerization to G protein-coupled receptor function. Furthermore, when the effects of these extracts on the production of macropahage-derived inflammatory cytokines such as interleukin-1alpha (IL-1alpha) and tumor necrosis factor alpha (TNF-alpha) were assayed, the red rice bran extract caused a stimulatory effect on the IL-1alpha production from mouse macrophages induced by LPS, but did not show a significant effect on TNF-alpha production.

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The photocatalytic activities were evaluated by measuring the degradation of methyl orange (MO) aqueous solution under visible light irradiation. Despite weak causal link, we emphasize that chest pain during ovarian stimulation protocol should rise clinical concern for acute coronary syndrome. To provide an update on recent studies on suicide prevention in indigenous populations with a focus on recently colonised indigenous peoples in Canada, the United States, Australia and New Zealand. The similarity observed in those two situations suggests that working memory uses already-existing memory apparatus by activating it temporarily.

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More data are needed to clarify if this relation is really a true biological phenomenon. Findings from these case studies, conducted at different levels of analyses (multistate vs single state) and using different research methods (qualitative vs quantitative), are reviewed, highlighting differences based on scope and methods. In the case of reduced flash-lamp excitation and a switched-off laser amplifier, the intensity fluctuations agree with the normalized Gaussian model for the fluctuations of the fundamental frequency, whereas strong deviations are found under usual operating conditions. Still little is known about naturally occurring synaptogenesis in the adult neocortex and related impacts of epigenetic influences. Esthetic needs in anterior tooth restoration: technique description.

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Pathologic quiz case: a 64-year-old man with hematuria, intracranial hemorrhage, and severe coagulation abnormalities. Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients. The mitotic activity of stem cells is activated by the cells themselves and is inhibited by differentiated cells. But these mechanisms are fundamentally at odds with the Weber law property of interval timing, and experiments that support linear encoded time can be interpreted in other ways. Univariate and multivariate random effects logistic regression models were used to explore the predictors of all reported cases of abortion (induced or spontaneous) and cases of induced abortion respectively.

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In a mixed population of relatives the proportion of pairs with closer family links increases with age, even if all marginal individual chances of survival are the same. This study suggests that SRH is a frequent accompanying symptom of epileptic seizures causing major impairment in daily life, and migraine is an important comorbidity of epilepsy, affecting the incidence and characteristics of SRH.

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Reduced grey matter metabolism due to white matter edema allows optimal assessment of brain tumors on 18F-FDG-PET. Results from neurocognitive testing, neuroimaging and EEG were compared with controls and/or correlated with heading frequency and/or head injuries. Simultaneously anterior decompression and posterior instrumentation by extrapleural retroperitoneal approach in thoracolumbar lesions. Because several structurally diverse antibiotics were detectable by ECL, this method may become valuable for the detection of many or all beta-lactam antibiotics and their inactivation by beta-lactamases. With the depth cube and a set of sample points for the tool object, a quick point-in-object test can be performed.

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As(2)O(3) treatment induced the loss of the mitochondrial membrane potential and an increase of ROS, as well as activation of caspase-3, -7, -9 and -10. Successful treatment of recurrent epididymo-orchitis: Laparoscopic excision of the prostatic utricle. The diagnosis of inflammatory pseudotumour was made on histopathological examination.

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Participation, control and career development were key work environment challenges contributing to the attrition on nurses from Lebanese hospitals. Size dependent optical properties like increase in the confinement energy with decreasing radius for different excitonic transitions are studied. The results showed that the only child did not differ significantly from his non-only peer in intelligence, school progress, referral reasons and the majority of mental health disturbances, but a significant difference was found in his increased submissiveness, greater number of repeat visits to clinic, and in the overprotective attitude of his parents.

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Further research is required to determine the effect of aging and hearing impairment on spatial processing and to investigate possible remediation options for spatial processing disorder. Students were interviewed with pretested questionnaire to sought information on demographic status, family type, knowledge of sexuality, and contraceptive usages. Subcutaneously tunneled, cuffed central venous catheters (CVCs) are commonly used in children undergoing cytotoxic chemotherapy or hematopoietic stem-cell transplantation. In one of these examples the sodium excretion patterns on 5 consecutive days under continuous saline infusion in one dog is evaluated.

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Both stents showed high safety, with no stent thrombosis in the TES group. Within the limitations of the study, there were few differences observed between the drugs with regard to hemodynamic variables, oxygen saturation, and overall percentage of objects recalled by patients sedated with either drug.

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Exposure to CT scans in childhood and long-term cancer risk: A review of epidemiological studies Clinical data from 254 patients treated for squamous cell carcinoma of the oropharynx between 1998 and 2003 were retrospectively analyzed.

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Conversion of PP to glucose-responsive insulin-secreting cells can be achieved by transplanting the progenitors in vivo where cell maturation occurs. The prediction of nasopharyngeal carcinoma mortality based on soil element levels in China.

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Alterations can be quantal (binary), either all or none, as with cell replication, cell necrosis or apoptosis, and cell differentiation, which take place at the cellular level. Spatial information of sodium concentrations during action potentials will provide insight at the cellular level on the role of sodium and how slight changes in sodium channel function can affect the entirety of an action potential. CNAP is a more efficient form of intraoperative monitoring than ABR during CPA tumor removal.

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Liver transplantation in management of alveolar echinococcosis: two case reports. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Furthermore, the magnetic resonance documentation of its early evolution has not been recorded. Qualitative papers were analyzed using JBI-QARI and involved categorizing findings and developing synthesized topics from the categories. Although conventional MRI has several advantages over other imaging modalities and is very useful in the differential diagnosis between brucellar spondylodiscitis and other spinal pathologies, it has some difficulties in discriminating acute and rhinolast nasal spray 22ml to inches chronic forms of spondylodiscitis.

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A simplified method for the analysis of ultracentrifuge film records of low-density lipoproteins of human serum. Cytokeratins 7 and 20 immunohistochemistry in ampullary carcinomas This learning-specific shift in brain activity was associated with a progressive change in the functional connectivity of these regions toward allopurinol uses the end of the first session. Desmosomes connect photoreceptor cells into the early imaginai stage and then disappear.

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After addition of an internal standard, triclosan is extracted at acid pH into petroleum ether, transferred to an alkaline aqueous solution, and back-estracted into petroleum ether after acidification. Synthesis, structures, and magnetic properties of heterodimetal bis(mu-hydroxo)chromium(III)nickel(II) complexes with Tpa derivatives having sterically bulky substituents. Thus, the purpose of this study is to perform a diagnosis and molecular characterization of BLV strains circulating in Korea and to estimate genetic diversity of different genotypes of flomax vs terazosin hydrochloride high BLV. Although behavioral deficits were not observed in mice neonatally treated with MSG at 1 month of age, a definite decline was manifested at 12 months and 34 months of age. In contrast, IFN-gamma and TNF-alpha production tended to increase in HIV-seropositive women with increasing hemozoin levels.

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Plasma and gastrocnemius muscle 3-methylhistidine, urine nitrogen, and plasma and urine urea concentrations were all significantly higher in the VAD group. Complex I and IV are the 2 most frequent abnormalities of the electron transport chain in humans. Cohesion between sister chromatids ensures accurate chromosome segregation, and promotes normal gene regulation and certain kinds mutabon forte 4 mg of DNA repair. Reconstruction of Transformation Processes Catalyzed by the Soil Microbiome Using Metagenomic Approaches.

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