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Ponaris (Fluconazole)
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Fluconazole

Ponaris is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zolax, Zoldicam, Zolen, Zoloder, Zucon,

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Are chlorine-free compounds a solution for health problems caused by ozone-depleting substances? Antibody and lectin binding was quantified in an enzyme-linked system. The ABRP transcripts in Agrius brain were shown to locate in four pairs of medial neurosecretory cells, the homologous group of neurosecretory cells that produce bombyxins in Bombyx brain.

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Concordance of renal stone culture: PMUC, RPUC, RSC and post-PCNL sepsis-a non-randomized prospective observation cohort study. In addition, inter-alpha-trypsin-inhibitor immunoreactivity was also demonstrated in human and rat mast cells.

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The areas of reduced sensitivity were larger than the areas of improved sensitivity (P less than 0.05), with a net negative change in sensitivity found in all cases. Introducing nanocarriers inside the halothane molecule can increase its benefits as an anesthetic in the lungs and cardiovascular system and prevent exposure to the liver. Assessment of the error in the recovery of continuous medical video information by its discrete counts Enzyme immunoassay: an improved determination of urinary albumin in diabetics with incipient nephropathy. We reviewed cost effectiveness studies to find a suitable model for Iranian population to determine the potential cost effectiveness of HPV vaccine program based on domestic available epidemiologic data.

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Perceived Neighborhood Safety Better Predicts Risk of Mortality for Whites than Blacks. Besides facilitating membrane recruitment of ADAP, SKAP55, and RIAM, SLP76 regulates TCR-mediated inside-out signaling by controlling the activation of Rap1 as well as Rac-mediated actin polymerization. The data obtained show that P does not depend on salt concentration (in the range from 2.10(-3) to 1 M) in adjacent solutions and ion species. Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice.

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Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. In cerebellar cortex, positive fibers began to radiate out from the white matter into the grey matter.

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Stent and patient related problems persist and may require additional intervention. Clinical signs were consistent with severe transverse myelopathy caudal to the brachial enlargement and cranial to the lumbosacral enlargement of the spinal cord. For a long time, shallots have been used as a source of food and medicine in Iran. Different antigenic reactivities of bovine brain glutamate dehydrogenase isoproteins. The effects of haematological adverse events on the prognosis of patients with gastric cancer were investigated.

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The patient tolerated the PEG-J well and his nutritional needs were successfully addressed. Prophylactic ICD therapy did not reduce overall mortality among patients with acute myocardial infarction and clinical features that placed them at increased risk. A total of 11 patients with one or more leg ulcers were treated. We tested for site-specific differences in FTO gene expression in subcutaneous and visceral adipose tissue (SAT and VAT, respectively) from individuals with and without type 2 diabetes mellitus (T2D) and the relationships between fasting glucose, in vivo insulin action, and measures of adiposity with FTO gene expression in adipose tissue. Molecular phylogeny of edge hill virus supports its position in the yellow Fever virus group and identifies a new genetic variant.

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Providing oxygen, improving tissue perfusion through augmentation of cardiac output, and administering antibiotics in a timely manner have all been shown to significantly improve outcomes in children with septic shock. Chronic Wounds: The Need for Greater Emphasis in Medical Schools, Post-graduate Training and Public Health Discussions.

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Differential phosphorylation of canonical CTD orchestrates transcriptional and co-transcriptional maturation of mRNA and snRNA. Technosphere is a safe delivery vehicle for medications administered via inhalation.

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IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. However if imaging findings are suggestive of pathology a biopsy should not be delayed. The development of widely accessible, effective psychological interventions for depression is a priority.

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The ISUIA has estimated the annual risk of rupture below that justifying surgery for most incidentally found lesions less than 7 mm in diameter. It would therefore seem that Con A exerts transmembrane control of effects induced by colchicine and cytochalasin B by binding to cell surface receptors and so triggering rearrangement of the cytoskeleton. Maternal anxiety and attention problems in children at 5 and 14 years. Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.

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Whilst GCxGC has been widely applied to identification of different types of analytes in several matrices, less seldom has it been used for quantification of these analytes. Dietary protein digestion and absorption plays an important role in modulating postprandial muscle protein synthesis. The aim of this study is to analyze the results of reduction aortoplasty with and without external prosthetic support. Monoclonal antibody recognition of HBP localized on membranes of sperm revealed variable binding patterns of M1 to the acrosomal region in sperm from bulls of known fertility. The anticancer property of salinomycin has been recognized and is based on its ability to induce apoptosis in human multidrug resistance (MDR).

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In submucosal glands, loss of CFTR-mediated salt and water secretion compromises the clearance of mucins and a variety of defense substances onto the airway surface. Effects of Autologous Serum Eye Drops on Conjunctival Expression of MUC5AC in Patients With Ocular Surface Disorders. Assessment of dexmedetomidine effects on left ventricular function using pressure-volume loops in rats. A novel multi-electrode pulmonary vein ablation catheter (PVAC) combining circular mapping and duty-cycled multi-electrode radiofrequency (RF) energy delivery has been developed to map and isolate the pulmonary veins (PVs).

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The above degranulation inhibition effect taken together with the pronounced bronchodilator property would confirm formoterol as a drug of choice in asthma with more efficient action than the other beta 2-stimulators such as fenoterol, salbutamol or isoprenaline. Clinical radiological note on skeletal manifestations of lymphosarcoma Greater attention to speciation of clinical yeasts and standardized susceptibility test methods are needed for future epidemiological surveillance.

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Novel pyridinium dyes that enable investigations of peptoids at the single-molecule level. The technique has been successfully used in 22 consecutive patients with no operative mortality and minimal morbidity.

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Although not dispelling the possibility of a concomitant antiatherosclerotic protection by antiplatelet treatment, this suggestion provides a useful guideline for the approach to primary prevention of cardiovascular mortality, in terms of treatment benefit expectancy, kind and size of population to test it, and type of drug to choose. Responses of goat ruminal musculature to bradykinin and serotonin in vitro and in vivo. We verified the effect of host species, sex, body mass and vertical strata in addition to the role of seasonality on the ectoparasite composition, richness and abundance.

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A maximal walking speed test over 10 meters and a 6-minute walking endurance test were done under standard conditions among 92 monozygotic and 105 dizygotic pairs of twin sisters reared together, aged 63-75 years. Although increased in all cases but two, the size of the right pulmonary artery remained remarkably less than normal in patients with an initially small right pulmonary artery.

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Polynomial regression analysis was performed using this data to get the best fit curves. However, statistically significant differences in both rates were only seen in one and two studies, respectively. Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil. In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems.

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Pain management during Royal Air Force strategic aeromedical evacuations. A bad five-year follow-up outcome of hypertensive disease depends on left ventricular mass index. Chirality emergence in thin solid films of amino acids by polarized light from synchrotron radiation and free electron laser. Poly(lactic acid) (PLA)/graphene nanocomposites were prepared by direct solution blending of PLA with graphene using chloroform as a mutual solvent. Enhanced intake of MC-SFA increased the lean body mass and caused a significantly lower total body-fat percentage compared with lower intake of MC-SFA.

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Bigeminal occurrence of infra-His blocked premature atrial contractions associated with carotid sinus syndrome. The human and bacterial A site rRNA binding as well as the aminoglycoside-modifying enzyme (AME) activity against a series of neomycin B (NEO) dimers is presented. Managing the wandering behaviour of people living in a residential aged care facility.

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Psychotropic drugs, anticonvulsants, and centrally acting antihypertensives may impede intellectual function and motor coordination. Glucose enhances rat islet function via stimulating CART expression. This paper provides an overview of these risk factors, outlines how they individually and in interplay endanger favourable outcome by putting patients at risk for poor self-management. Temperature-dependent studies indicated that the thermodynamics of solute partitioning is similar on both the single-chain and double-chain IAM.PC surfaces. Surgery allows for the complete cure from the diseases when the removal of adenoma is complete.

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Meanwhile the survival and weight change of snails in the two groups were recorded, and were compared with those snails cultured in water under the corresponding temperature conditions mentioned above. The quantitative expression of each T cell site was affected by the proteolysis inhibitor leupeptin, resulting in partial inhibition of site 1, complete blocking of site 2, but enhancement of site 3. Cholelithiasis was not unusual in children less than 11 years old. The growth of 41 children (age 1.92-13.2 years) with steroid-dependent nephrotic syndrome (SDNS) was studied using recordings from clinic visits over the course of their follow-up at Great Ormond Street Hospital (study period range 1.38-8.43 years, mean 4.2 years, total 172 years). Fluorescent whole-mount method for visualizing three-dimensional relationships in intact and regenerating adult newt spinal cords.

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In contrast, substance P and CGRP-containing terminals showed only a transient fall in expression in the first week following nerve section and then staining was no different from that seen on the control side. Weight changes following the diagnosis of type 2 diabetes: the impact of recent and past weight history before diagnosis.

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In addition, mice immunized with the combination vaccine were prophylactically protected from genital challenge with high doses of live Chlamydia and HSV-2. X-ray and optical diffraction studies of the flexuous papaya mosaic virus are described. Orthognathic surgery is indicated for the treatment of significant skeletal malocclusion and is normally prepared using conventional face bows combined with two-dimensional cephalometric analysis and manually made splints. We demonstrated that Hsp60 complexed with specific antibodies induces a strong classical pathway (CP) activation.

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The conventional r2 values are 0.93 and 0.87 for CoMFA and CoMSIA, respectively. The number of injured cells increased successively during the re-perfusion period. The inactivated gp64 gene was cloned into the AcMNPV viral genome by replacement of the wild-type gp64 efp locus. We used univariate and multivariate logistic regression analyses to assess the impact of these variables on ICU mortality. Specific symptoms of antisocial personality were associated with hysteria and were identified.

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A glycoprotein from the liver constitutes the inner layer of the egg envelope (zona pellucida interna) of the fish, Oryzias latipes. Eelectron microscopy of zygospore formation in Chlamydomonas reinhardii. To achieve enhanced and economical production of target molecules, the development of strong auto-inducible promoters is desired, which can be activated without expensive inducers and has significant advantages for industrial-scale use.

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Of the studies cited by Hobbis and Sutton (this issue), only one measured health behaviours. We identified six emerging themes from the literature and stakeholder interviews: cost and resources, risk assessment, governance and consensus building, customization, clinical workflow and usability testing, and training. Inhibitors of the TGF-beta superfamily and their clinical applications. Changes in the polyadenylation of specific stable RNA during the early development of Xenopus laevis. Changes in ribonuclease in the central nervous system of mice during morphine dependence development, withdrawal and naloxone administration.

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Taking research beyond laboratories: exploiting commercial potential. The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. The authors report two Japanese patients with lattice corneal dystrophy type II related to FAP-IV. The effect of mouthrinses on salivary sorption, solubility and surface degradation of a nanofilled and a hybrid resin composite.

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Gastroenterology consultations may largely benefit from an HRC system with only organizational changes and no additional costs. In the former category, most methods involve one allele in the bacterial chromosome and another in a plasmid, but it is also possible to detect recombination between two chromosomal alleles or between two extrachromosomal alleles. Bacteria in a hospital nursery: laboratory and clinical studies. The early diagnosis of apical HCM can be achieved by identifying the hypertrophy frequently confined to the lateral wall at the apical level. Adolescent personality and/or family environment were related to 1) major depression, conduct disorder, and attention deficit/hyperactivity disorder in both boys and girls, 2) oppositional defiant disorder, post traumatic stress disorder and overanxious disorder in girls, and 3) dysthymic disorder and alcohol use in boys.

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Tutorial-based assessment, despite providing a good match with the philosophy adopted by educational programmes that emphasize small group learning, remains one of the greatest challenges for educators working in this context. Academic health sciences libraries in the United States and Canada were surveyed regarding collection development trends, including their effect on approval plan and blanket order use, and use of outsourcing over the past four years. These individuals demonstrated evidence of volume expansion and sodium-dependent hypertension.

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In addition, we showed that agonist stimulation of the alpha(1A)-adrenoceptor induced resistance to thapsigargin-induced apoptosis and that caveolin-1 was necessary for this process. Thrombin-stimulated phospholipase C activity is inhibited without visible delay by a rapid increase in the cyclic GMP levels induced by sodium nitroprusside.

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Five pulmonologists with expertise in fiber-optic bronchoscopy but novice to the SGI participated. This paper presents a psychological picture of seven women with a particular focus on some psychodynamic considerations underlying their wish to remain childless and the role of the psychiatrist in the decision-making process for this procedure. Clinical trials have suggested that coenzyme Q10 supplementation can effectively lower blood pressure (BP). Specifically, AteIF5A-2, one of the three eIF5A genes in Arabidopsis (Arabidopsis thaliana), is shown to regulate programmed cell death caused by infection with virulent Pseudomonas syringae pv tomato DC3000 (Pst DC3000).

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The incidence of type 1 diabetes is increasing in both children and young adults in Northern Italy: 1984-2004 temporal trends. We have experimental data indicating that the pancreas is easily damaged by any intervention. COX-2 activity moves in parallel with changes in NOS I and intrarenal renin. This modality is a minefield, where one careless movement can bring disaster.

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We investigated the genetic predisposition to juvenile diabetes in the families of 31 index cases in relation to the inheritance of the HLA system. Influence of trypsin on the regeneration of hyaline articular cartilage. Using the mechanosensitive channel of large conductance (MscL) as a model system, we obtain relations between the shape of MscL and the supramolecular architecture of MscL lattices. Pediatric First Aid Practices in Ghana: A Population-Based Survey.

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The analysis of available literature reveals few publications concerned with evaluating quality of life in people with RA in both the objective and subjective dimensions. In this work an immobilized form of PCR, known as polony technology, was adapted to quantify the relative expression levels of splice variants. A 74-year-old man experienced intraoperative electromagnetic interference that resulted in asystole caused by surgical electrocautery in the coagulation mode while the electrodispersive pad was placed at different locations and distances from the operating site (This electromagnetic interference did not occur during the use of the cutting mode). Our results point to there being further genetic information on Yp that also has a role in restructuring the sperm head.

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Long-term survivors accepted a skin graft from Brown-Norway donors at 80 days, but rejected grafts from an unrelated donor. The fast MRI method of skipped phase encoding and edge deghosting (SPEED) is further developed with array coil enhancement, and thus is termed SPEED-ACE.

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The higher molecular weight complex of 260 kD may result from dimerization of the receptor. ii) To assess prognostic parameters for response to treatment and for improvement of QoL parameters. We report on regular spatial patterning in Carex stricta in a freshwater wetland and investigate the applicability of theoretical models that explain regular patterning based on inhibition, facilitation, or interaction between the two. Reagents which inhibit disulphide bond formation stabilize human fibroblast interferon. For each eye, the cumulative distribution of RA/DA was calculated from 36 equally spaced rim sectors of each optic disc obtained by the automatic evaluation of simultaneous videographics (Image-net X Rev.3/51b).

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Treatment concepts for restoration of endodontically treated teeth: A nationwide survey of dentists in Germany. It highlights common overlap in physical and social pain systems and how a physical painkiller can reduce the pain of social exclusion. There was minimal accumulation of protons during the exposure period, as suggested by minor differences in pH(i) of cells with or without prior exposure to vinyl acetate. Ladybird (Lbx) homeodomain transcription factors function in neural and muscle development--roles conserved from Drosophila to vertebrates. Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children.

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Participants were 93 adolescents in poor metabolic control diagnosed with insulin dependent diabetes and their primary caregivers. Seasonality of reproduction in wild boar (Sus scrofa) assessed by fecal and plasmatic steroids. In the cardiac intensive care unit, a variety of risk factors were significant. The results show that compared to a German control group, the MMN response is less robust in Turkish-German children to the German vowel contrast. We have addressed the energetics and the position specificity of nonnative hydrophobic interactions by developing a continuum coarse-grained chain model with a native-centric potential augmented by sequence-dependent hydrophobic interactions.

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Midtrimester genetic amniocentesis with simultaneous ultrasound guidance. Tandem fusion, centric fusion, and chromosomal evolution in the cotton rats, genus Sigmodon. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia.

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Comparable effects of percutaneous transluminal septal myocardial ablation and subaortic ventriculotomy in treating patients with hypertrophic obstructive cardiomyopathy, an echocardiography follow-up study While it is clear that some behavioural methods, alarms and desmopressin can be effective interventions, the evidence for other absetzen cipralex symptoms of pneumonia treatments is not so definitive.

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In order to obtain stable LB films, the influences of different parameters - type of amphiphile, surface pressure and pH - on the properties of mixed IgG/amphiphile monolayer, were investigated. This review evaluates the clinical evidence of the effects of positioning of preterm infants with regard to physiological outcomes and sleep states. Therefore, when frailty is erythromycin dose for gi motility medications severe, delivery of palliative care focused on relief of discomfort and enhancement of quality of life is highly appropriate.

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The objective of this article is to analyze published reports of hybrid procedures involving complete visceral debranching of the aorta and endovascular exclusion of the thoracoabdominal aortic aneurysms. Under uniplex drug enforcement general anaesthesia nine mongrel dogs were first injected with fenoteral 0.06 mg/kg/per minute and later with fenoteral 0.06 mg/kg/per minute and verapamil 2 mg/kg/per minute.

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The study population consisted of patients enrolled in the Triple Site Versus Standard Cardiac Resynchronization Therapy trial. In addition, we report three-dimensional reconstructions and volumes of cerebrospinal fluid, cerebral ventricles, total white matter (WM), total gray matter (GM), cerebral hemispheres (WM and GM), cerebellum and brainstem combined (WM and GM), and hippocampal structures bactrim used for urinary tract infection all derived from magnetic resonance images. Using chimeric receptors, mutagenesis, and molecular modeling, we reveal how these sweet enhancers work at the molecular level. FCD type IIIa according to the new ILAE classification) than in adult series has been reported. Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel

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