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Sipralexa (Escitalopram)

Sipralexa is the S-isomer of the racemic compound citalopram, a selective serotonin reuptake inhibitor (SSRI) that is widely used in both psychiatric and primary care practices for the treatment of depression. The theoretical rationale for separating a single isomer from its parent compound and synthesizing it into a new therapeutic agent is 2-fold. First, it may capture the molecule that is actually responsible for the desired therapeutic action. At the same time, it may isolate and remove the molecule that is not only therapeutically unproductive but may be the source of undesirable pharmacologic activity. The result is a “purer” agent, one that can potentially offer an improved safety and efficacy profile versus the parent compound.

Other names for this medication:
Escitalopram, Lexapro, Aramix, Celtium, Cipralex, Citoles, Ectiban, Entact, Esertia, Esipram, Esita, Eslorex, Esram, Gaudium, Lexamil, Lextor, Losiram, Losita, Neozentius, Nexcital, Seroplex, Sipralexa, Tiopram,

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Long-term use of alosetron is effective and well-tolerated in women with chronic, diarrhea-predominant IBS, including those with more frequent urgency. These results provide the basis for the further study on the role of caveolin-1 gene in other scopes. These results suggest a phonologically based productive deficit which interferes with the learning of g-p rules.

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Data on age, obstetric history, possible etiological factors, treatment and pregnancy outcomes were evaluated. Esophageal impedance and esophagitis in children: any correlation?

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To obtain representative data on incidence and psychological background of tattooing and body piercing. From February 2012 until November 2014, all patients with esophageal atresia and distal tracheo-esophageal fistula were subjected to preoperative tracheobronchoscopy.

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Histopathologic changes of architectural disarray, pleomorphism, increased mitotic activity, vascular invasion, hemorrhage, or necrosis were generally reliable criteria for diagnosis of malignancy. Amperometric hydrogen peroxide biosensor based on the immobilization of HRP on nano-Au/Thi/poly (p-aminobenzene sulfonic acid)-modified glassy carbon electrode. A modified nephrostomy in the management of urinary fistula after renal transplantation. Differentiated THP-1 cells were preconditioned with subthreshold concentration (0.03 microg/ml HSP-70) for 18 h, followed by LPS stimulation (1 microg/ml) for 4 h. He was treated with beta interferon injections for multiple sclerosis for 3 months.

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It is unclear which of several surgical, radiotherapeutic, ablative, and surveillance treatments is the most effective. The mortality rate is diverse and depends on severity of the disease. Since its discovery in the late 1990s, Pten has turned out to be one of the most important tumor suppressor genes.

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Uracil DNA glycosylase (UDG) removes uracil from U.A or U.G base pairs in genomic DNA by extruding the aberrant uracil from the DNA base stack. Using the ONIOM hybrid method to apply equation of motion CCSD to larger systems: benchmarking and comparison with time-dependent density functional theory, configuration interaction singles, and time-dependent Hartree-Fock.

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High-field, high-resolution MR imaging of the human indusium griseum. UK abortion law allows terminations for fetal abnormality without gestational limit. Cinefluorographic motion picture production technics including cinefluorographic data analysis. ESR of copper and iron complexes with antitumor and cytotoxic properties. As part of a larger study the use of nocturnal penile tumescence monitoring has been examined as a possible outcome measure.

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Improving the wear resistance of conventional artificial denture teeth is of value to prosthodontic patients. Total and specific IgE in sera from patients with invasive amoebiasis. The latter were treated over a 5-day period with HU alone or HU plus specific inhibitors of prostaglandin, leukotriene and nitric oxide synthetic pathways. Characterized by real-time glucose-responsive insulin administration, closed-loop systems combine glucose-sensing and insulin-delivery components.

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The occurrence of postoperative upper airway oedema was significantly related to the extent of the intubation trauma. Taken together, obesity can impair male fertility through declines in the sperm function parameters, sex hormone level, whereas during spermatogenesis damage to the blood-testis barrier (BTB) integrity may be one of the crucial underlying factors accounting for this change. The photoluminescence spectra has revealed visible to near infrared emission for Se NPs.

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Dewatered alum sludge: a potential adsorbent for phosphorus removal. rapa has a distinct organization of ancestral genome blocks as a result of recent whole genome triplication followed by a unique diploidization process.

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Unilateral versus bilateral ASCP administration did not result in different mortality and neurologic morbidity rates. Wellbeing and Arthritis Incidence: the Survey of Health, Ageing and Retirement in Europe.

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However, compared to acquisitions that employ thick slices, MRI acquisitions with isotropic sampling have a lower signal-to-noise ratio (SNR). Level of oral hygiene was examined clinically using the Simplified Oral Hygiene Index (OHI-S), and an interviewer-administered questionnaire was used to measure key socio-demographic variables and psychosocial and health-related behaviours. Granulocyte-macrophage colony-stimulating factor (GM-CSF) can increase embryo development to the blastocyst stage in cattle. To date, the primary approaches for the rehabilitation of this sequela are Applied Behavior Analysis, Cognitive-Behavior Therapy, and Comprehensive-Holistic Rehabilitation Programs. These results highlight the crucial role that the stage of gestation plays on the course of ovine neosporosis, similar to that reported in bovine neosporosis, and open the doors to consider sheep as a valid model for exogenous transplacental transmission for ruminant neosporosis.

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In the adult brain, sensory cortical neurons undergo transient changes of their response properties following prolonged exposure to an appropriate stimulus (adaptation). TROP2 overexpression promotes proliferation and invasion of lung adenocarcinoma cells. Experimental, clinical and radiographic studies on the use of a special matrix and matrix-holder in conservative therapy Alternatives to X-ray crystallographic techniques are needed to probe the structure of the hetero-oligomeric lens protein alpha-crystallin.

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Serum lipids, lipoproteins, hemodynamics, and hemostasis in doxazosin-treated monkeys. Structural Brain Changes in Mood Disorder: Clinical Correlates and Significance.

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This review aims to give an overview of one of those advances, the use of botulinum toxin. HLA typing using isoelectric focusing--use of a simple and practical method in general practice of tissue typing We apply our methods to the Massachusetts General Hospital glioblastoma study. Intrapartum fetal head position II: comparison between transvaginal digital examination and transabdominal ultrasound assessment during the second stage of labor.

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Transitional cell carcinoma of bladder during pregnancy: case report. Possibly the failure to eradicate the tuberculosis is linked to the pathogenesis of the causative organism, Mycobacterium tuberculosis. Absence of characteristic clinical findings make the diagnosis difficult.

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At various postoperative days contact microangiography, stereoangiography, microdensitometry and histology were performed. All case-patients had received a corticosteroid injection from a multidose vial.

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However, before large-scale clinical trials can take place, a few safety concerns have to be clarified, such as atherogenesis, postangioplasty or stenting restenosis, tumorigenesis, stem cell metastasis, stem cell-mobilized cytokine-related complications and arrhythmogenesis. Construction of other molecular skeletons with minimal use of protecting group manipulations should be feasible.

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Optimizing time and temperature of enzymatic conversion of isoflavone glucosides to aglycones in soy germ flour. In general most of the evidence indicates a beneficial change in the renal pathology and function in animals with glomerulonephritis receiving L-arginine.

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A study is presented in which the feasibility of two-dimensional strain rate estimation of the human heart in vivo has been demonstrated. To model the factors associated with depression in a community sample of people with epilepsy.

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The particularities of the case in comparison with the known data from the literature are the partly more active MS plaques and extensive necroses of the glioblastoma, especially on the tumourous margins, immediately in the neighbourhood of MS plaques. Pollen of Bermuda grass (Cynodon dactylon) is an important cause of pollinosis in many areas of the world.

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Paraphyly of North American sections suggests that taxonomic revision is warranted. Dynorphin B, which has the same length and charge as the peptide, had some blocking activity. Two task conditions without and one condition with arithmetic demands were administered. The cytopathological alterations observed in cells infected with isolate 6712 were similar to those found previously with aphid-nonspecific isolates transmitted most efficiently by Rhopalosiphum padi-, and Macrosiphum avenae-specific isolates of BYDV, while the other three isolates differed in the presence of the proliferated, membranous inclusions.

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Characterization of pre-antibiotic era Klebsiella pneumoniae isolates with respect to antibiotic/disinfectant susceptibility and virulence in Galleria mellonella. We report the case of a 72-year-old man with aortic stenosis and mitral insufficiency who was diagnosed with ochronosis while undergoing surgical aortic and mitral valve replacement.

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Smoking is definitely associated with peptic ucler but the mechanism is unknown. Further, the change of actual ejaculation caused by manual stimulation of the penis was observed after excision of the nerves.

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A depolarizing response to increased bath potassium concentration (HK) was observed that was linearly related to the absolute value of the Vbl under control conditions. Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen. Interactions between pulmonary surfactant and alveolar macrophages in the pathogenesis of lung disease. The VPL System is a relatively efficient and safe treatment for long-term hair removal.

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Double mutants which contain a nonsense mutation and a deletion in trpE were constructed, and the degree of transcriptional polarity was estimated by the decrease in messenger RNA for the operator-distal trpE beyond the nonsense mutation, as well as by the production of truncated messenger RNA for the region of trpE proximal to the nonsense mutation. Porous cups with and without hydroxylapatite-tricalcium phosphate coating: 23 matched pairs evaluated with radiostereometry. Trichoid sensilla from the male antennae of a second species, Utethesia ornatrix, did not exhibit similar heterogeneity between ridge edges versus planar areas with regard to hydrogen bonding with the SiO(2) hydrophilic tip. Here, we examine the functions of a deeply conserved regulator of morphology in three fungal species: Saccharomyces cerevisiae, Candida albicans, and Histoplasma capsulatum. The increased input of RL into an antigen-stimulated LN and the decreased cell output from the LN can occur independently and are possibly controlled by different mechanisms.

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Conversely, the ability to link early brain injury to subsequent cerebellar development has challenged previous understanding of the distinction between acquired and primary dysgenesis, presumed to be genetic in origin. Mitral stenosis (MS) is the most common valvular heart disease revealed or exacerbated by pregnancy. Chemoradiotherapy followed by monthly temozolomide (TMZ) is the standard of care for patients with glioblastoma multiforme (GBM). Surgeons are involved both in the resection and the reconstruction of these tumors and in the management of late sequelae of earlier treatment.

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EHDP significantly inhibited bone resorption in these co-cultures. Biomonitoring of workers occupationally exposed to diesel exhaust was performed to determine their internal burden of diesel associated aromatic compounds. It is well known that web-based interventions can be effective treatments for depression. The frequency of symptoms in patients with and without hepatitis C were compared. Modifications in surgical approach and technique and selection of the appropriate analgesic protocol may improve outcomes in dogs and cats after thoracic surgery.

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The three common variants of the vitamin D binding protein, also known as group specific component (Gc), namely types 1S, 1F and 2, as well as some rare variants were studied by thin-layer polyacrylamide gel isoelectric focusing in a pH 4.5-5.4 carrier ampholyte generated pH gradient, additionally containing N-(2-acetamido)-2-aminoethanesulfonic acid (ACES). The clinical features of both children resembled the typical symptoms reported for older patients with this disease: psychomotor deterioration, movement disorders, and seizures. A new signal sequence trap using alkaline phosphatase as a reporter.

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Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands. The results suggest that NTPs inhibit the rates of ion uptake and exchange reactions at concentrations much lower than their intracellular physiological concentrations. Myocardial blood flow following experimental coronary occlusion. Fine structural features of lymphocyte transformation by pokeweed mitogen. To compare target dose distribution, comformality, normal tissue avoidance, and irradiated body volume (IBV) in 3DCRT using classic anatomical landmarks (c3DCRT), 3DCRT fitting the PTV (f3DCRT), and intensity-modulated radiation therapy (IMRT) in patients with locally advanced rectal cancer (LARC).

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The ascending afferents were collaterals of the LL fibers distributed mainly in the inferior colliculus. The present study aimed to investigate the inter-relationships between bowel function, excess body weight and dietary intake in a group of preadolescent children. Haematological, immunological and endocrinological aspects of blood transfusions with either freshly collected or preserved donor blood were investigated in chronically cannulated unrestrained rats.

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Our results support recent contentions that rodlet cells comprise part of the host inflammatory defence response. We have previously shown that the interaction between dynein-dynactin complexes is clearly attenuated in aged monkey brains, suggesting that dynein-mediated transport dysfunction exists in aged brains. Prevalence of human papillomavirus in Indonesia: a population-based study in three regions. In this method, two polypeptides are expressed in yeast as fusion proteins to a transcriptional activator DNA-binding domain (bd) and activating domain (ad), respectively. Biopsy specimen cultures were positive in ten patients, while aspirate and blood cultures were positive in five and two, respectively.

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In conclusion, these results indicate that P4 is a potent regulator of GnRHRI at the transcriptional level as well as GnRH I mRNA. Contrasting solvent polarity effect on the photophysical properties of two newly synthesized aminostyryl dyes in the lower and in the higher solvent polarity regions. This new physio-pathological approach gives a better comprehension of the clinical features than phenotype classification based on plasma cholesterol and triglycerides levels and lipoprotein electrophoretic pattern. Developing cultural competence in general practitioners: an integrative review of the literature.

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Ten days after impact, the water content and the fibronectin content of the loaded region of the explant were both increased. The blood serum lactate dehydrogenase (LDH), creatine kinase (CK), and LDH isoforms activities have been measured in 103 patients with the compression neural and myodystrophic syndromes of lumbar osteochondrosis. Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells.

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These cell lines were of three types: (1) Taxol-producing with and without methyl jasmonate, (2) Taxol-producing only upon elicitation, and (3) nonproducing. In vivo perfusion with paraformaldehyde and picric acid, followed by demineralization in a solution of either EDTA-cacodylate or buffered EDTA-sucrose, proved to be the most appropriate with respect to preserved antigenicity. Thus, two types of signaling mechanisms are operative in the down-regulation of cell proliferation genes during osteoblast differentiation--one that impinges on regulatory sequences that influence the interactions of transcription factors with cis-acting promoter elements and a second that modulates messenger RNA turnover. Contextual fear conditioning is a form of associative learning where animals must experience a context before they can associate it with an aversive stimulus. Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis.

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Conversely, overexpression of Bcl-xL suppressed, and its knockdown promoted, the apoptosis of chondrocytes. The innate immune system initially appears to contain the pathogen at the site of entry. The primary objective of this article is to examine the extent of self-reported non-adherence among patients participating in a controlled trial of an asthma compliance optimization intervention.

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There were, however, inter- and intra-group divergences in regard to these ideas, especially in the PG. DNA sequencing revealed a close phylogenetic relationship between the pathogen populations.

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Although the field of tissue engineering has come a long way since its first successful demonstration by Bisceglie in the 1930s, methods of coaxing them into functional tissues have been predominantly empirical to date. Computed tomography (CT) showed enhancing, perivascular, linear, and nodular areas along the subarachnoid space, extending deep into the white matter. Quantitative evaluation and real-world case studies demonstrate the promise of our approach, especially in support of examining a topic-graph-based full picture at different levels of detail. No single method is always preferable and the best way of detecting a particular tumor recurrence is based on the location and nature of the primary tumor. Although there is growing evidence of relationship between obesity and some specific stone compositions, results were inconsistent.

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Stem cells and their descendents are the building blocks of life. Simulations are carried out and discussed in order to illustrate the advantages and disadvantages of SOMS compared with traditional OMS. The last section summarizes the specific histologic lesions of primary biliary cirrhosis, primary sclerosing cholangitis, their histologic mimics, and the differential diagnosis with drug-induced cholestasis and ductopenia. On examination limbal ischemia was more in the left eye (9 clock hours) than the right eye (2 clock hours). There was no correlation between serum folate and haematocrit or reticulocyte count.

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Enzymes involved dexilant 60 mg vs omeprazole capsules in the oxidative metabolism of n-6 polyunsaturated fatty acids, like lipoxygenase (LOX) and cyclooxygenase (COX), are significant in the pathogenesis of colorectal cancer. The existence of such yin yang haplotypes has important implications for statistical methods for analysing rare variants.

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Among these, an association between the serotonin transporter gene and response to serotonin reuptake inhibitors appears robust. The results of this trial demonstrated no drug-related short-term improvement on the primary outcome measure, or any of the secondary outcome measures. We hypothesized that the association between self-ratings of micoral shampoo coupons change and both outcomes would be greater among individuals without dementia than among those with dementia. Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report.

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Similarity-based interference during language comprehension: Evidence from eye tracking during reading. Western blot was used to detect the columnaris tetracycline for acne expression of phosphorylated ERK1/2 at 40 ng/mL HGF after 0, 5, 30, 90 and 120 minutes. Many trials to date have investigated the diagnostic accuracy of coronary computed tomography angiography (CCTA) when compared to the gold standard diagnostic test, invasive coronary angiography. Binding of inositol stereoisomers to model amyloidogenic peptides. It is shown that the behavior of such tubes is well represented by an analysis in which the discharge plasma is supposed to radiate as a blackbody.

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Immediate resection under total cardiopulmonary bypass should be performed before catastrophic complications occur. Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells. To survive or to slay: Resource-foraging dalfaz uno 10 mg ulotka kaufland role of metabolites implicated in allelopathy.

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The leukaemia cell lines were particularly sensitive to the compound, as were the majority of the colon cancer, melanoma and breast cancer cell lines, while the central nervous system-derived lines and the non-small cell lung cancer lines were particularly resistant. apton hall cats for sale We assessed a novel simultaneous biventricular mapping and ablation approach for septal ventricular tachycardia (VT) in a chronic ovine infarct model. In the third we examined offspring of doubly affected parents, 10 spouse pairs with ALS, 3 spouse pairs with PD and 13 spouse pairs in which 1 spouse had ALS and the other PD.

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The repair was done using single layer repair, with successful results. Given the potential for Viagra (sildenafil) use to foster greater friction during sex (owing to enlarged omnic 0 4mg capsules pills erection size) and prolonged sex, the recreational use of this substance warrants investigation in the context of STI risk. The QRS complexes in leads V1-V3 revealed an R wave at LAD and a QS pattern at normal axis. Editorial comment on: human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP cells. Although the nuclear phosphoinositide system is likely to be a primordial forerunner of the plasma membrane system, relatively little is known about it.

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Global MTR values for the pepzol capsule wardrobe group of normal subjects and for the group of MS subjects were characterized by 30 different measures involving simple statistics, histographic characteristics, MTR order information, and MTR range information. The medical records of 150 node-negative stage IA2-IIA cervical cancer patients who had DSI and/or LVSI after RHPL from 1999 to 2004 were reviewed. Further on, signs predominated suggestive of deep thrombophlebitis of the lower extremities. RNA expression was measured ex vivo via microarrays and quantitative RT-PCR.

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The metalinguistic ability to cope with homonyms, that is, words having multiple unrelated meanings, emerges rather late in the course child language development. It is essential to perform a careful neurological evaluation, including sensory examination of the lower bicalutamide pills limbs, as well as neuroradiological and neurophysiological assessments to avoid confusion with motor neuron disease and to detect the coexistence of amyotrophic lateral sclerosis, especially when surgical treatment of cervical spondylosis is planned. Effectiveness of laceback ligatures on maxillary canine retraction. Moreover CHI3L1 was higher in the SF than in serum of JIA patients, and it positively correlated with the frequency of Th17 and non-classic Th1 cells in SF.

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Therefore, in studies of dynamic cellular processes, it would be ideal to be able to combine the capability of in omestad 40 mg morphine vivo fluorescence video microscopy with the EM. Purification and preparation of prion protein: synaptic superoxide dismutase. Treatment with intravenous immunoglobulin and milrinone are recommended in cases with severe neurological complications from EV71 infection, such as brainstem encephalitis. In the control condition, no consistent differences in EMG levels between internal and external subjects were obtained. However, resistance to RA is often observed, which limits its clinical utility.