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Topigen (Topiramate)
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Topiramate

Topigen was first approved in the United States in 1996 for treatment of epilepsy. Topigen has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topigen has high bioavailability and low binding to serum proteins. Salivary Topigen levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topigen in adults from 20–30 h to 12 h. Children typically clear Topigen faster than adults.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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The above biochemical changes were not temporally related to inhibition of acetylcholinesterase (AChE). Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.

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Neither aBMD nor the FRAX captures cortical porosity, a major determinant of bone strength. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

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The McMaster Health Utility Index Mark 3 (HUI3) is used as a more objective health measure than the simple five-point scale of self-assessed health. multiple myxoid mammary fibroadenomas, and the Cushing syndrome, and an affected brother had acromegaly caused by a growth hormone-secreting tumor of the pituitary gland.

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A wide range of human factors approaches have been developed and adapted to healthcare for detecting and mitigating negative unexpected consequences associated with technology in healthcare (i.e. This study investigates the effect of varying the test parameters of lens power, target size, test distance, and test duration on binocular accommodative facility. Completely reversible, severe, acute neurological deterioration with an otherwise asymptomatic, huge intradiploic calvarial epidermal cyst. Using a His-tagged Aac2 derivative and affinity purification studies, we also demonstrate here that the Aac2 isoform can be affinity-purified with other AAC proteins. Further, 56 percent of enrollees in marketplace plans attained cost-sharing reductions in 2015.

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Clinical experience with EPID dosimetry for prostate IMRT pre-treatment dose verification. Differential diagnosis of mild pulmonary stenosis and small atrial septal defects. Five sites of nerve graft were harvested: lateral and medial antebrachial cutaneous nerves (LABCN, MABCN), posterior and anterior interosseous nerves (PIN, AIN), and sural nerves.

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Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel. Whether rhGH therapy improves muscle protein mass and force in individuals with severe cachexia associated with major trauma, burns, surgery, or muscular dystrophy is controversial and under investigation. The review, although partly idiosyncratic, covers such major areas of therapy optimization as phase-specific chemotherapy, antiangiogenic therapy and therapy under drug resistance. The activation of dorsolateral prefrontal cortex (dlPFC) has been suggested to reflect the engagement of a control mechanism for top-down biasing of context processing in resource-demanding memory tasks.

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The method is based on the ability of G-quadruplex ligands to displace hemin from G-quadruplex-based DNAzyme, resulting in a decrease of its catalytic activity on the fluorescence-developing reaction between p-hydroxyphenylacetic acid and H(2)O(2). Two enzymes of the Leloir pathway, UDP-GlcNAc pyrophosphorylase and UDP-Glc dehydrogenase, which are involved in the synthesis of activated sugar nucleotides have been cloned, overexpressed in Escherichia coli, and purified to homogeneity in only one step by chelation-affinity chromatography. Complementation analyses using wild-type trxA or a genetically engineered trxA coding for noncatalytic TrxA showed that the catalytic activity of TrxA is essential for SPI2 activity in phagocytic cells whereas a noncatalytic variant of TrxA partially sustained SPI2 activity in epithelial cells and virulence in mice. Evidence suggests that the three antibodies are directed against monomorphic determinants but that they recognize different epitopes. To better account for influence of impulsivity in these psychiatric disturbances, no single source of measurement should be used without the consideration of other types of instruments.

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Orosomucoid in proliferative malignant diseases of the hematopoietic system and its level during treatment Intracellular activity gradients that regulate localized mitotic events bare several hallmarks of self-organizing biologic systems that designate spatial information during pattern formation.

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This system is maintained by complex metabolic machinery, which is regulated at different levels according to environmental factors such as light, CO(2), and nutrient availability. Suppression of the anaphylactic response of isolated smooth muscle organs by potassium arsenite The toxicity of ribosome-inactivating proteins increased after conjugation to IgG or homopolymerization. Secretion of monocyte chemotactic activity by alveolar macrophages. Network analyses using three functionally diverse enzyme superfamilies illustrate the use of these approaches for facile updating and comparison of available structures for a large superfamily, for creation of functional hypotheses for metagenomic sequences, and to summarize the limits of our functional knowledge about even well studied superfamilies.

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Adrenergic regulation of blood pressure in chronic renal failure. There are no essential differences between the results of both preparations. The aims of the study were to examine tooth and enamel disturbances in individuals with 22q11.2 deletion syndrome and to analyze associations with medical conditions, birth characteristics and blood values of calcium and PTH.

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Normal cartilage was collected from five human knees at the time of autopsy. Significance of vagal afferentation and cerebral oxygen supply in the complex of perinatal changes of CNS After PTZ administration, mice showed myoclonic seizure (MCL) and clonic seizure (CL) in order.

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Technetium-99m HL91 uptake as a tumour hypoxia marker: relationship to tumour blood flow. Approximately half of the patients treated with RC without neoadjuvant chemotherapy for clinical T1G3 UCB are upstaged to muscle-invasive UCB. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. Heme-independent soluble and membrane-associated peroxidase activity of a Zea mays annexin preparation. Synthesis of carbasugar C-1 phosphates via Pd-catalyzed cyclopropanol ring opening.

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By using capillary electrophoresis, we showed that Gne can catalyze the interconversion of both UDP-GlcNAc/GalNAc and UDP-Glc/Gal almost equally well. Alcohol consumption and route of contamination differed between HCV-infected and HCV/HIV co-infected patients. In the course of phagocytosis we noted the presence of peroxidase less evidently in both subcellular structures during the first of 5 minutes. The operator is called innovative variation and is fundamentally different from traditional crossover operators, since new genetic material is included in the offspring which is not contained in one of the parents. Abnormal sperms with reduced hook, bent neck, coiled flagellum, bent flagellum and bent flagellum tip were significantly increased in treated rats.

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Neurodevelopmental outcome at 12 months of age related to cerebral ultrasound appearances of high risk preterm infants. We show that obstetrician-gynecologists and medical institutions are moral co-fiduciaries of female and pregnant patients, that the obstetrician-gynecologist should be economically disciplined without capitulating to managed care, and that managed care organizations have an obligation to support the medical education and research from which they benefit. This active-site similarity was then used to verify that chelerythrine, a known Bcl-xL inhibitor, also binds PrgI. The individual VCA achieves a better radiographic limb and femoral component alignment than fixed VCA in our study patients.

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Some show a statistically superior survival for the group receiving chemotherapy compared with a best supportive care group, while the others show no advantage. Over the years, several clinical conditions, as well as errors in blood component preparation and administration, that mimic AHTR have been identified. To describe the evolution of controlled ovarian hyperstimulation in women with recurrent ovarian endometriomas treated with sclerotherapy. Enhancement of protein translocation across the membrane by specific mutations in the hydrophobic region of the signal peptide. Analysis of cellular components, biochemical reactions, and habitat of human cutaneous lipophilic diphtheroids.

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We report four cases of cryptococcosis presenting as upper limb cellulitis or ulceration, or both. The placement of demented patients in long-term institutional care can be deferred with the support of a dementia family care coordinator. Reliance on (210)Pb chronology can compromise the inference of preindustrial Hg flux to lake sediments.

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CFS, as diagnosed by Centers for Disease Control and Prevention criteria, is not a clinical entity reliably associated with reduced GMV. A number of truncated recombinant soluble CD4 (sCD4) molecules have been produced and shown to easily neutralize infection of laboratory strains of HIV-1 in vitro, and clinical trials using these sCD4 preparations have begun in patients with AIDS.

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This treatment, of moderate toxicity, improves the quality of life and can result in long-term tumor stabilization. These are the first documented cases of pineocytoma with this type of clinical presentation. Thus in patients, who referred severe pain during sialography, antiinflammatory drugs are recommended to control the onset of pain after sialography.

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In a study designed to maximize the effectiveness of treatment by allowing participants to select the target of treatment, 40 depressed older adults were randomly assigned to a waiting-list control condition or to conditions in which the target of treatment was either chosen or assigned. A decrease in histamine content was observed 10 min after provocation compared to the values obtained before provocation (P less than 0.05).

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It is essential however, before this can be put into wide clinical practice, that a reliable isolation procedure and a simple, robust means of genotyping rare fetal cells be developed. The medial frontal cortex indirectly controls vocalizations, based on the recognition of social context.

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Recognition of specific disease patterns in this group is important and best managed by a dedicated team. Secondary end points included time to onset of delirium, number of delirium-free days, length of intensive care unit stay, all-cause 28-day mortality, and adverse events. The primary purpose of these experiments was to determine the impact of 5-HT receptor stimulation, with particular focus on 5-HT(1B) receptors in the nucleus accumbens on the reinforcing effect of amphetamine.

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Heat shock proteins: therapeutic drug targets for chronic neurodegeneration? Accordingly, current evidence points to roles for these Cxs in several important regulatory mechanisms in the kidney, including the renin angiotensin system, tubuloglomerular feedback, and salt and water reabsorption. This has rendered dendritic cells accessible to detailed experimental evaluations and clinical applications. Those effects can be parameterised and quantified with the IBS which thus enables an efficient and purposeful training.

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Factor analyses found parents and adolescents identified and prioritized the same six factors: education and career planning, abuse and victimization, adolescent behavior problems, adolescent sexuality, socioeconomic stressors, and relationships. We demonstrate its ability to focus scenes containing large amounts of phase error regardless of the phase-error structure or its source. It is suggested that alteration of the skin by e.g., prolonged contact with pondwater, the presence of small wounds and the advanced age of the birds, acting as predisposing factors may be necessary in establishing this disease. In the contralateral kidney, autophagy was also induced and prolonged during UUO. This system successfully modified the in vivo input rate of CLP without compromising oral bioavailability.

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The developmental delay, the marked progressive neurological deterioration and the daily seizures suggested surgical resection. There are many reports concerning glucocorticoid-induced thymocyte apoptosis, but little is known about the participation of thymic stromal cells, especially the thymic epithelial (TE) cells, in the apoptosis.

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Squamous cell carcinoma in chronic ulcerative lesions: a case report and literature review. The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membrane. In this study, we analysed whether tumour-associated antigen (TAA)-specific CD8 T-cell responses could be induced by vaccination in old mice with metastatic breast cancer.

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Hypoxic and anoxic events, although less common, appear to carry more morbidity for the patient and are associated with greater settlements and judgments in malpractice claims. It deals with the issues of Lithium levels, concomitant usage of Phenothiazine and addresses the important question of toxicity occurring at normal serum Lithium levels. Technical advances over the last few years, such as improved sample preparation and electron detection methods, have been instrumental in obtaining data with unprecedented structural details.

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Confounding of pain intensity with affect caused by use of smiling and crying anchor faces is a disadvantage of the WBFPRS. The performances of the developed immunosensor and Dot-ELISA were tested against different dilutions of hyper immune serum (rabbit anti-PfHRP-2). To investigate the role of proton MR spectroscopy in pediatric cerebellar tumor diagnosis. There was no difference in the effect of intravenous glucagon between normal subjects and patients suffering from the above-mentioned disorders.

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Standard conditions for toxin isolation and presentation to larvae are sought. An overlooked entity in children with rectal bleeding: solitary rectal ulcer. The aim of this study is to assess the efficacy of a cognitive-behavioural psychological intervention, delivered by primary care psychologists in patients with mixed anxiety-depressive disorder compared to usual care. The presence of hydroxyproline in granules and calcium spherites gives reason to believe that a fibrillar protein related to the collagen-type might occur within these structures. Furthermore, the results confirm the hypothetical model that injury preventing behavior is determined by intention, attitude, social norm and self-efficacy.

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Hyperglycemia and hypertriglyceridemia among persons with coronary heart disease. It is concluded that low-frequency filtered clicks can be used to complement unfiltered clicks in order to obtain a more complete objective audiogram.

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The local root-mean-square roughness increases with decreasing size of water droplet. Team-level job satisfaction ratings are a potentially important marker for the effectiveness of primary care teams in managing patient care. A preparatory coloring book can help meet this need by providing factual information and by allowing emotional expression. The cross-talk of two redox factors, H2O2 accumulation and redox status of photosynthetic electron transport (PET) in tobacco chloroplasts, on the expression of cytosolic ascorbate peroxidase (cAPX) was studied. However residual lymph node structures, venules, PAS-positive material, and reticulum cells did not correlate with survival data.

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To compare bony pelvis dimensions between white women with and without genital prolapse using computed tomography (CT) pelvimetry. Cross-sectional imaging in a case of adventitial cystic disease of the popliteal artery. The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles. To elucidate the mechanism of gastric hypersecretion induced by cysteamine, the effects of atropine, cimetidine, proglumide, cromolyn sodium and tranilast on the cysteamine response were studied in rats. Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.

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Simultaneous enrichment of shiga toxin-producing Escherichia coli O157 and O26 and Salmonella in food samples using universal preenrichment broth. A prospective analysis was made on the clinical data of 349 patients with both a diagnosis of hip fracture and an operative delay of greater than 72 hours between April 2014 and February 2016.

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Neutrophils, Helicobacter pylori, and nonsteroidal anti-inflammatory drug ulcers. Influence of individualized training on psychomotor performance of young soccer players. In this report the dissociate expression of these respective genes in various liver diseases or after exposure to estrogen is emphasized. Erythroid differentiation regulator 1 (Erdr1) is known to be a stress-related survival factor exhibiting anti-cancer effects in several cancers.

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His symptoms remained refractory to benzodiazepines, nerve blockage, and botulinum toxin injection due to either poor compliance or lack of response to therapy. The effects of agitation, sediment, and competition on the persistence and efficacy of Bacillus thuringiensis var. Acute intoxication with low ethanol doses led to an increase in the spectral power and coherence in the frequency band of the dominating theta-rhythm peak (5.75-7.25 Hz), which was indicative of activation of the septo-hippocampal system (with improvement of the related functions such as attention, memory, and exploratory activity). Comparatively, the current clinical chemotherapeutic standard, temozolomide, was significantly less effective in inducing glioblastoma cell death. Pharmacodynamic screening and simulation study of anti-hypoxia active fraction of xiangdan injection.

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we extracted the peripheral blood samples from 150 patients with gastric cancer and 150 control subjects. Pleomorphic adenoma is the most common benign tumor of the major salivary glands. Its histologic appearance is distinctive, being characterized by cells with a moderate amount of cytoplasm having a ground glass or finely granular appearance, a distinct cell wall that stains with eosin and PAS, and enlarged nuclei with prominent nucleoli.

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Proteomic analysis identifies candidate proteins associated with distant recurrences in breast cancer after adjuvant chemotherapy. Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation. Preganglionic sympathetic neurones innervating the rat adrenal medulla: immunocytochemical evidence of synaptic input from nerve terminals containing substance P, GABA or 5-hydroxytryptamine.

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The determinants of mother-to-child transmission and the pathogenesis of symptomatic fetal infection remain poorly understood. The paper describes the medico-legal language style of texts which are often meant for non-medical scholars.

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The fact that these findings were consistently observed in the nerves of all species studied argues strongly in favor of the existence of a uniform structural pattern of distribution of elastic system fibers in nerves as a general phenomenon in mammals. Possible role of opsonins in adsorption and transport of biological membranes and viruses by Staphylococci

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Moreover, the impact of increased BNP in patients with sepsis is not clear. Changes in the flomaxtra tamsulosin hydrochloride side kinin system in sudden death caused by coronary circulatory disorders

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FABP4 is expressed in a significantly higher percentage of GBMs in comparison to both citoles medicine bow normal brain tissues and lower-grade glial tumours. In the present study, we investigated the expression of the transcription factors krox-20 and c-jun, positive and negative regulators of myelination, respectively.

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Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. report that the connecting tubule is also the major segment in electrogenic urinary acidification, thus reinforcing the central role of this segment in overall electrolyte transport. We manipulated the compatibility of stimulus-response mappings (Experiment 1) and the compatibility of the target with flankers (Experiment 2). Rat lung tissues were processed fluconazole 100 mg 7 capsule hotels for the localization of both type IV collagen and SP-A by high-resolution immunocytochemistry, applying the protein A-gold technique with specific antibodies.

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This mobile element contains the subrepeats of only A ethambutol dose in tbis and B types, all sites of transcription initiation, the open reading frame and the inverted repeats on both ends, flanked by the short direct repeats. Enzymatic cross-linking versus radical polymerization in the preparation of gelatin PolyHIPEs and their performance as scaffolds in the culture of hepatocytes. Diminished inibitory action of ethanol on the contraction of gallbladder isolated from chronically ethanol-fed Guinea pigs.

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In five of the seven epithelioid sarcoma patients, CA 125 levels reflected regression and progression of their disease. Fibroblast growth factor receptor expression in outer hair cells of rat cochlea. However, conventional immune suppressive agents have limited clinical efficacy in chronic GVHD, and prolonged immune suppressive treatments result in additional toxicities that further limit clinical recovery from transplant and return to normal daily function. Although sequence diversification has produced GSTs with multiple functions, the structure of these proteins has been highly conserved. spironolactone iv administration of diluted The MAO-B activity was significantly lower in the F group than in the S group.

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Recurrent laryngeal nerve paralysis is an extremely rare complication of neuroborreliosis associated with Lyme disease. Furthermore, BrBmcys2b was detected in saliva and different tissues along tick stages, while BrBmcys2c was detected mainly in gut from partially engorged R. It was found that IGF II transcripts were present in biaxsig 300 side effects abundant quantities in first trimester embryos as well as in the extraembryonic tissues amnion and allantochorion. Identification of functional variants within these regions and a characterization of the effect of these risk genotypes on the treatment of specific clinical symptoms are needed.

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Advanced stage at diagnosis and inadequate treatment of older cancer patients are associated with poor survival. It is challenging to design a reliable and practical instrument to predict difficulty in surgical extraction of cyclophosphamide cytoxan price impacted lower third molars. All three had been alcohol-dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation.

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The human myeloid leukemia cell line HL60 was treated with LD-Ara-C in combination with anti-Fas IgM MoAb, and apoptosis in the treated cells was estimated by morphological observation, DNA electrophoresis and flow cytometry. The mice with the fluconazole 150 mg cuando hace efecto de luna shortest sleep time (HS-SS) and the mice with the longest sleep time (HS-LS) were selected and tested for the effect of ethanol and muscimol on chloride flux in cerebellum.

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Quantitative high-performance thin-layer chromatography determination of common liposome components and critical parameters influencing the analysis results. Successful treatment of azole-resistant chronic mucocutaneous candidosis with caspofungin. Epilepsy is a common neurologic condition in women of reproductive age. A chromosome analysis showed that there were ten identifiable marker chromosomes and sex chromosomes with its modal number of 64. The affected segment was found to be a 55cm portion of terminal ileum at operation which was resected due to hypertrophied proximal and collapsed distal segments, features in supacef action games keeping with chronic intestinal obstruction, and ileo-ileal anastomosis done.

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A MSFD complementary approach for the assessment of pressures, knowledge and data gaps in Southern European Seas: The PERSEUS experience. Further research using new measurement tools should help refine these results. Patients with a history of multiple detoxification episodes are more likely to experience seizures and severe withdrawal symptoms. The afferent and efferent connections of the torus semicircularis (TS) of larval sea lampreys were studied with horseradish gabaneural 400 mg peroxidase, carbocyanine dye (DiI) and fluorescein-coupled or Texas-Red-coupled dextran amine tract-tracing methods.

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