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Topimax (Topiramate)

Topimax is a very potent anticonvulsant that is structurally different from other AEDs. It is derived from D-fructose and initially was developed as an antidiabetic drug. In animal models, it was found to have potent antiepileptic effects. Topimax has multiple mechanisms of action. It exerts an inhibitory effect on sodium conductance, decreasing the duration of spontaneous bursts and the frequency of generated action potentials, enhances GABA by unknown mechanisms, inhibits the AMPA subtype glutamate receptor, and is a weak inhibitor of carbonic anhydrase. Topimax is absorbed rapidly after oral administration and has a bioavailability close to 100%. When it is administered at regular doses, food delays but does not affect the extent of absorption.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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The influence of polyhydric alcohols and carbohydrates on the thermostability, i.e., the heat inactivation kinetics, of Bacillus licheniformis alpha-amylase was studied in the temperature range 96 degrees to 130 degrees C. Totally asymmetric transcription of coliphage T7 in vivo: correlation with poly G binding sites. The recent differences in outcomes based on histology observed in period 4 may reflect the increased activity of epidermal growth factor receptor tyrosine kinase inhibitors in adenocarcinoma compared with squamous cell carcinoma.

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Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. UDPglucose pyrophosphorylase catalyses the interconversion UDPglucose plus pyrophosphate and glucose 1-phosphate plus UTP. The purpose of this study was to determine the characteristics of individuals who participate in the National Veterans Wheelchair Games (NVWG) and the Winter Sports Clinic (WSC) for veterans with disabilities. Functional disability is reported frequently in fatigued cancer patients, but little is known about the correlation between fatigue and objective physical function. Computed tomography dose measurements with radiochromic films and a flatbed scanner.

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Various over-the-counter topical products commonly used by patients have failed to demonstrate any significant benefits in improving final scar outcomes. Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age. Steady-state two-dimensional maps of very alkaline proteins in an immobilized pH 10-12 gradient, as exemplified by histone types. OTA daily intake was estimated based on OTA plasma concentrations and on the food consumption data combined with food contamination data taken from the literature. An increase in the number of treatments paralleled a statistically significant increase in tattoo clearance for all three Q-switched lasers.

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Such antibodies can destroy infected cells by ADCC or delay the virus spread, and therefore, should be considered in immunisation strategies against HIV. Eight nursing homes will be randomly assigned to either an experimental or control group.

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Thus sub-chronic administration of ionized Cd produces morphological and functional changes in rat salivary glands. The ultrasound measurement of IMT in the common carotid artery (CCA), carotid bulb and common femoral artery (CFA) was performed.

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Analysis suggested conserved behaviour and high similarity in active sites of WsSGTs with other plant GTs. Recently, the structure of the HCN2 COOH-terminal region was solved and shown to contain intersubunit interactions between C-linker regions. The treatment of ocular tuberculosis: a survey of published literature. Eleven patients underwent the treatment, and five resulted to achieve a stable functional improvement, as assessed by the proposed algorithm.

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Stochastic transport in the presence of spatial disorder: Fluctuation-induced corrections to homogenization. Findings are discussed in terms of family-level substance use and similarities in developmental trajectories across substances, and the impact of contextual factors on family levels of substance use and development.

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Isolated bladder metastasis causing large bowel obstruction: a case report of an atypical presentation of intussusception. For the prazosin group the average blood pressure on monotherapy was 146/81 mm Hg (supine) and 151/88 mm Hg (erect), and for the verapamil group the corresponding figures were 149/81 and 156/92 mm Hg. To investigate the macrophage migration inhibitory factor (MIF) expression and -173 G/C polymorphism of the MIF gene in nonalcoholic fatty liver disease (NAFLD). Hepatic dysfunction may be a manifestation of polymyalgia rheumatica.

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Analysis of the transcription of the gene showed the presence of two potential translation initiation codons in some ALATS mRNAs. Patients had a PSA (midPSA) measured after a course of external beam radiation (EBRT) before planned transperineal low-dose-rate brachytherapy implant (LDR). Children With Conduct Problems and Co-occurring ADHD: Behavioral Improvements Following Parent Management Training. Mature VNR beta is glycosylated by not fully processed oligosaccharide side chains because it remains endoglycosidase H (endo H) sensitive, even when the complex is expressed on the cell surface.

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In this study, we demonstrate that iloprost-induced angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays multiple biological activities in the vascular system. To identify the benefits and harms of using laparoscopic compared to open nephrectomy techniques to recover kidneys from live organ donors.

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Mottled MR appearance of a hyperacute intracerebral hemorrhage at 0.5 T. Lack of sensitivity to readmission: a grounded theory study for explaining the process of readmitting patients suffering from congestive heart failure.

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Prion diseases are characterized by the intraneuronal accumulation of a pathological isoform (PrP(Sc)) of host-encoded prion protein (PrP(C)). The available evidence suggests that similar signaling cascades may be involved and particular protein activities may be conserved between plants and yeast. The treatment and four-year follow-up of a malignant paranasal sinus and anterior skull base schwannoma is described. We show that Kin1 and Kin2 physically interact with the t-SNARE Sec9 and the Lgl homologue Sro7, proteins acting at the final stage of exocytosis. Pharmacological cardioversion of atrial fibrillation: current management and treatment options.

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Blind areas of cardiac imaging during transesophageal echocardiogram/endoscopic ultrasound. Six of nine studies that measured patient health outcomes showed significant but small improvements as a result of the use of clinical guidelines.

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The contribution of intrafractional motion to residual random errors has to be evaluated. For each cause of death, the expected number of deaths was calculated from vital statistics for the State of Iowa for the time period of follow-up. A 12-year-old girl with dystrophic epidermolysis bullosa presented to our clinic with a symblepharon connecting the lateral half of the left upper lid to the upper temporal quadrant of the cornea. Chronic hepatitis C is one of the leading causes for chronic liver disease globally.

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Nicotinamide mononucleotide adenylyltransferase 1 gene NMNAT1 regulates neuronal dendrite and axon morphogenesis in vitro. in 1992, the CGH assay has been widely used for identification and characterization of both numerical and structural chromosome abnormalities in cells of different tissues at various pathological conditions in humans, especially in tumor diseases. In all tissues, whether normal or malignant, striking VEGF positivity was seen in plasma in vessels and stroma.

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Using a sensitive and novel reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay system, we found that IL-5 messenger RNA (mRNA) was constitutively expressed in bronchial biopsies obtained from healthy individuals, and that the levels of IL-5 mRNA expression decreased 1. Fabrication and electrochemical treatment application of a novel lead dioxide anode with superhydrophobic surfaces, high oxygen evolution potential, and oxidation capability. Such metabolomics platforms were mostly based on mass spectrometry (MS) technologies enabled by a combination of different ionization methods together with a variety of separation steps including LC, GC, and CE.

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Spinal cord ischemia reperfusion (IR) injury causes inflammation and subsequently increases blood-spinal cord barrier leakage and Toll-like receptor 4 (TLR4) pathway activation. Together with the literature review, these cases demonstrate the important clinical features of cardiac metastases from melanoma and define the best means of diagnosis as well as the potential benefits of surgical intervention.

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In girls, but not in boys, the association between depression and BMI was mediated by cortisol reactivity. The probability of preterm birth was not increased with high DBP exposure. The structure of an unusual ordered aggregate of papaya mosaic virus protein.

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The vacuum suction mechanism of laser drug injection is discussed. August 1997 updates of MEDLINE and EMBASE databases, using the Datastar online system. Experiments on mechanisms of metastasation: dependence on reaction susceptibility in the host. Cleavage of 5,6-CFDA occurred within the xylem parenchyma cells, and the non-polar 5,6-CF was then symplasmically transported to other parenchyma elements and ultimately, via numerous pore plasmodesmata, to adjacent thick-walled sieve tubes. The information available for assessing radiation hazard involved in prolonged space missions is so far insufficient.

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Purchasers hold different views from providers and users about what the objectives of genetic counselling should be. We evaluated the prognosis of 17 pregnant women who developed Q fever with and without co-trimoxazole (trimethoprim-sulfamethoxazole) treatment. Knowing the limitations of applied deep brain stimulation technology for a clearer understanding of clinical outcomes. The structures of the new compounds were elucidated from their spectral data (IR, MS, 1H- and 13C-NMR, 1H-1H COSY, and 1H-13C HETCOR) and by chemical derivatization.

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Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. Therefore, these patients should not be denied an important diagnostic procedure that may improve their quality of life purely because of hypertension or age. Interactive electron-density map interpretation: from INTER to O.

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During male meiotic prophase in mammals, X and Y are in a largely unsynapsed configuration, which is thought to trigger meiotic sex chromosome inactivation (MSCI). Bioavailability of oral vitamin E formulations in adult volunteers and children with chronic cholestasis or cystic fibrosis. Treatment with eupatilin significantly decreased neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 levels in urine, blood urea nitrogen level, and serum creatinine levels, as well as kidney tubular injury. Based on available literature and standards of care, a survey was presented to each panelist.

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Given that the odors of 4 of the 6 amino acids tested here were detected at concentrations lower than their corresponding taste detection thresholds, this may have important implications for the widespread use of amino acids as food additives as well as for the evaluation of off-flavors caused by amino acids. Observed rotation is continuous around an axis perpendicular to the laser beam axis, with the frequency increasing linearly with the laser power.

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Neurogenesis occurs in two germinal centres of the adult brain and persists with increasing age, although at a reduced level. Does gastric tonometry-guided therapy reduce total mortality in critically ill patients? The electronic transport properties of ternary Cd(1-x)Zn(x)S nanowire networks. At some point during the transport, the complex is rendered soluble by proteolytic cleavage of the membrane-associated SC molecule to release the soluble sIgA into the gland lumen or the canaliculus. Prostate-specific antigen (PSA) immunohistochemistry in the presence of a normal serum PSA as an aid to diagnosis of adenocarcinoma of unknown primary site.

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Aneurysm clips are cost and clinically effective in the management of dural injuries. dGEMRIC allows direct assessment of cartilage matrix biochemistry and may depict the complex damage pattern of hip joint cartilage after LCPD spatially and qualitatively better than other radiographic methods. However, outcome values have often been confounded with the physical changes in the outcomes themselves.

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Management of donors and blood products reactive for hepatitis B virus DNA. A comprehensive literature search found 349 articles that referred to bariatric surgery in older adults. Resveratrol is a phenolic compound found in grapes and other food products.

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A systematic review of literature and quality assessment was performed in order to identify questionnaires that were developed to identify adult women with endometriosis. Chromosomal abnormalities in Finnish orofacial cleft patients: excess of submucous cleft patients? The bone mineral density (BMD) was significantly lower in the immediate irradiation groups.

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This effect was dose-dependent, reversible after removal of DEX, and was partially blocked by progesterone in excess, indicating a receptor-mediated response. The material of profile radiographs of 23 patients was collected in Denmark in the 1970s.

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Progressive polyarthritis in children and adolescents as a social problem Here, we demonstrate induction of the oxidant-resistant phenotype in mesangial cells by silencing the wild-type (WT) p66ShcA gene.

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All randomised controlled trials or other quantitative research designs were considered in the absence of RCTs. These effects are mediated by a melanopsin-based photoreceptor system that is very sensitive to blue light (440-480 nm) relative to the three-cone visual photopic system. The vacuolization in the eccrine glands of the skin, another striking feature, has not been reported previously in ALD. The aim of the present experiments was to evaluate the relative biological effectiveness (RBE) of monoenergetic 2.5 MeV neutrons, in view of the scarcity of data on the RBE of neutrons in this energy range. DegS has both kinase and phosphatase activity and our findings demonstrate that the phosphatase activity of DegS is essential to control the level of DegU phosphate.

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In patients with AD, the use of tumor necrosis factor (TNF) antagonists has had unpredictable results. Until we can better understand what constitutes health and illness in all adult populations, we risk repeated occurrences of unexplained symptoms among veterans after each war. The crystallographic structure of the lead compound, 4-methyl BPBI, was used as a starting point to model the inhibitors in both the mutant bound and the unbound states. We included all patients who were treated with gentamicin at our centre over a 1-month period. Development of deforestation and land cover database for Bhutan (1930-2014).

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The five monoclonal antibodies generated included three IgG2a and two IgM antibodies and were studied for antigen specificity using recombinant PDC-E2, recombinant BCKD-E2, histone, dsDNA, IgG (Fc), collagen and a recombinant irrelevant liver specific control, the F alloantigen. Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents. This analysis from blood and hair samples produced reproducible and clear PCR-RFLP patterns and DNA sequence match with those expected for horse, while the urine sample results were coincident with human. Transport time and early treatment--important factors in knife injuries Lymphocyte radiosensitivity was measured using the alkaline comet assay, the micronucleus assay, the nuclear division index and morphological assessment of apoptosis.

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Rapid Correction of Chronic Hyponatremia Secondary to Psychogenic Polydipsia: Hypoxic Injury or Extrapontine Myelinolysis? Electrically addressed 256 by 256 liquid-crystal-on-silicon spatial light modulator. Information on the presence or absence of HER2 overexpression can be obtained in CTCs. Encephalopathy subsequent to accidental poisoning with chlorpromazine. Deviations of amplitude and phase of radio-frequency pulses from the desired values, can have a severe impact on the performance of multiple-pulse sequences in NMR spectroscopy.

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Pioglitazone acutely influences glucose-sensitive insulin secretion in normal and diabetic human islets. All eyes showed similar clinical features and profound visual loss mainly due to delayed diagnosis.

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Probabilistic spectral model of color halftone incorporating substrate fluorescence and interface reflections. It was demonstrated that maximum damage and repopulation of the tumour cells emerge at 24 and 48 h, respectively, following PDT, suggesting that subsequent light treatment should be performed within 24 h to enhance the therapeutic effect of PDT. Insertion there seems to cause chromosome rearrangement and thus RB2 is considered one of the important elements for initiation of chromosome rearrangement. This association is postulated to arise, at least in part, as a result of a systemic proinflammatory state that is mediated by adipose tissue.

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In H-35 cells, both B-10 IgG and insulin stimulated tyrosine phosphorylation in an endogenous 185,000 mol wt protein. This technique is used to enhance sensitivity and also, in the case of cobalt coordination, to assist in carbohydrate structural elucidation. Nonetheless, information about sensory inputs is communicated in the form of spike trains. Graded compression sonography with adjuvant use of a posterior manual compression technique in the sonographic diagnosis of acute appendicitis. Estimation of sampling uncertainty for determination of pesticide residues in plant commodities.

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The program led to a significant reduction of self-rated migraine pain intensity. A radiolabeled control McAb that did not recognize HBsAg failed to discriminate between either the HBsAg positive and negative tumors or other tissues from nude mice. Furthermore, the enzyme initially removes an acetyl group from the nonreducing-end residue of all chitin oligomers with a degree of polymerization higher than 2, and further catalyses the hydrolysis of the following acetamido groups in a processive fashion. We have experimentally found a correlation between the nonlinear characteristics of frequency-doubling optical fibers and a specific acyclovir ointment generic modification of their Raman spectra.

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Importantly, we also show that blood samples can be fixed prior to cell staining fromilid 500 mg uno hockey which enables shipping of samples making the technology widely available. Patients with ulcerative colitis (UC) are prone to colorectal cancer and dysplastic polyps and also have sporadic adenomas. Site-directed mutagenesis revealed that an active-site cysteine within mApg7p is Cys(567), indicating that mApg7p is an authentic E1 enzyme for murine Apg12p and mammalian Apg8p homologs.

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To understand the mechanism for the refractoriness of B-chronic lymphocytic acog guidelines herpes pregnancy acyclovir leukemia (B-CLL) cells for Epstein-Barr virus (EBV)-induced immortalization. In spite of the falling trend, mortality among children and young people in Poland continues to be higher than that observed in most European Union countries (Poland ranks 19th in a total of27).

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Cellular and free lipopolysaccharides (LPS) obtained from Neisseria canis and N. An in vitro study was done to analyze the effectiveness of probiotic BIFILAC on P. The dental hygienist on the dental menards dermatology bactrim for sinus health team today and tomorrow.

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vulgaris and its isoquinoline alkaloids (particularly berberine). In addition, we show that STEAP1 knockdown reduces Ewing tumor proliferation, anchorage-independent colony formation as well as invasion in vitro and decreases growth and metastasis of Ewing tumor xenografts in vivo. Good reproducibility and a high SNR were achieved by combining several methods for combutol 800 tablet covers water suppression and by using the displaced variant of U-FLARE. T lymphocytes and genetic studies have shown that it is strongly associated with HLA-DR4.

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Brassinosteroid-induced changes of lipid composition in leaves of Pisum sativum L. For replication, the genome scan and analyses were repeated on 693 people from 93 families (DS-2). Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and erythrocyte binding proteins/ligands (EBLs). As a part of a larger Health Technology Assessment (HTA), the measurement error of a device used to monitor the hemoglobin concentration of a patient undergoing surgery, as well as its decision consequences, were to be estimated from published data. Prospective metronidazole dose unica 8 comprimidos trazodona observational substudy conducted within a randomized controlled trial.

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The dynamic loss and gain of introns during the anxiron 10 mg tabletta promo evolution of the Brassicaceae. The systematic sequencing of the yeast genome has raised the problem of the biological significance of the open reading frames (ORFs) revealed: it is possible that some of these are fortuitous. The necessary and sufficient condition for the assumption to be valid is derived. These associations remained significant when adjusting for covariates relevant to the aging process.

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Antibiotics with activity against community-associated MRSA, such as trimethoprim-sulfamethoxazole and clindamycin, are preferred empiric therapy for outpatients with cellulitis in the community-associated MRSA-prevalent setting. The main outcome measure was change in diflucan dosing for vaginal yeast infection mean diurnal intraocular pressure after 6 months of treatment compared with baseline.

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Effect of alcohol feeding igor cotrim elvis e madonna children mode on the biosynthesis of poly (3-hydroxybutyrate-co-3-hyroxyvalerate). Several analytes can be oxidized by conducting diamond compared to other carbon-based materials before the breakdown of water in aqueous electrolytes. The passive stability characteristics of ankle braces depend to a great extent on being used in combination with a shoe. We suggest that in NAGS deficiency, some secretory proteins might be incompletely processed due to the lack of a protease activator, NAG.

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With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. Stepwise excavation may enhance pulp preservation in permanent teeth affected by dental caries. In German-speaking countries, the intravenous treatment ciprotan tablets for children of ankylosing spondylitis (AS) with radium-224 ((224)Ra) was common between the late 1940s and 2005. To investigate the effect of continuous high volume hemofiltration (HVHF) on respiration, hemodynamics, and oxygen metabolism in severe sepsis patients with acute respiratory distress syndrome (ARDS). The nucleic acid content of the liver and spleen in mice after the prolonged action of vitamin B 12

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Allergen-specific IgG(4) titres and IgG-associated inhibitory activity were evaluated. In particular, we have found that HA35 induces the expression of tight junction protein zonula occludens (ZO)-1 in both healthy and Citrobacter infected mice, as demonstrated by immunoflurorescence and Western blot analyses. A novel series of maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones were prepared to lansazol 30 mg fiyati investigate the efficacy of micronutrient conjugation in enhancing cytotoxic potency by improving selectivity and delivery. In this paper, we present a new approach to predicting MHC-binding ligands that takes into account new weighting schemes for position-based amino acid frequencies, BLOSUM and VOGG substitution of amino acids, and the physicochemical and molecular properties of amino acids. No changes were observed in PPE mRNA expression in the SCN in response to any of the experimental conditions.